SN 003

Modify Date: 2025-09-14 17:25:52

SN 003 structure	Common Name	SN 003
	CAS Number	197801-88-0	Molecular Weight	355.43400
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₉H₂₅N₅O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of SN 003

SN003 is a reversible antagonist of corticotropin releasing factor receptor 1 (CRFR 1) (IC50 = 241 nM) that displays more than 1000-fold selectivity over CRFR 2. SN003 suppresses CRF-induced ACTH release in vitro. SN003 attenuates depressive-like behavior in rat[1][2][3].

Name	1-(1-Methoxy-2-butanyl)-N-(4-methoxy-2-methylphenyl)-6-methyl-1H- [1,2,3]triazolo[4,5-c]pyridin-4-amine

Description	SN003 is a reversible antagonist of corticotropin releasing factor receptor 1 (CRFR 1) (IC50 = 241 nM) that displays more than 1000-fold selectivity over CRFR 2. SN003 suppresses CRF-induced ACTH release in vitro. SN003 attenuates depressive-like behavior in rat[1][2][3].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> CRFR Research Areas >> Neurological Disease
References	[1]. J S Dileep Kumar, et al. Synthesis and in vivo evaluation of [11C]SN003 as a PET ligand for CRF1 receptors. Bioorg Med Chem. 2006 Jun 15;14(12):4029-34. [2]. Andrzej Wróbel, et al. Inhibition of the CRF1 receptor influences the activity of antidepressant drugs in the forced swim test in rats. Naunyn Schmiedebergs Arch Pharmacol. 2017 Aug;390(8):769-774. [3]. Simeon J Ramsey, et al. Quantitative pharmacological analysis of antagonist binding kinetics at CRF1 receptors in vitro and in vivo. Br J Pharmacol. 2011 Oct;164(3):992-1007.

Description

Related Catalog

Signaling Pathways >> GPCR/G Protein >> CRFR

Research Areas >> Neurological Disease

References

[1]. J S Dileep Kumar, et al. Synthesis and in vivo evaluation of [11C]SN003 as a PET ligand for CRF1 receptors. Bioorg Med Chem. 2006 Jun 15;14(12):4029-34.

[2]. Andrzej Wróbel, et al. Inhibition of the CRF1 receptor influences the activity of antidepressant drugs in the forced swim test in rats. Naunyn Schmiedebergs Arch Pharmacol. 2017 Aug;390(8):769-774.

[3]. Simeon J Ramsey, et al. Quantitative pharmacological analysis of antagonist binding kinetics at CRF1 receptors in vitro and in vivo. Br J Pharmacol. 2011 Oct;164(3):992-1007.

Molecular Formula	C₁₉H₂₅N₅O₂
Molecular Weight	355.43400
Exact Mass	355.20100
PSA	74.09000
LogP	3.86580
InChIKey	FZMBHAQCHCEGNN-UHFFFAOYSA-N
SMILES	CCC(COC)n1nnc2c(Nc3ccc(OC)cc3C)nc(C)cc21

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SN 003

Use of SN 003

Names

SN 003 Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.