Thalidomide-O-C8-NH2

Modify Date: 2024-01-17 05:41:29

Thalidomide-O-C8-NH2 structure	Common Name	Thalidomide-O-C8-NH2
	CAS Number	1957235-91-4	Molecular Weight	401.46
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₁H₂₇N₃O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Thalidomide-O-C8-NH2

Thalidomide-O-C8-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].

Name	Thalidomide-O-C8-NH2

Description	Thalidomide-O-C8-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate
Target	Cereblon
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References	[1]. Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-1008.

Molecular Formula	C₂₁H₂₇N₃O₅
Molecular Weight	401.46
Storage condition	2-8°C

DC Chemicals Limited
China
Product Name: Thalidomide-O-C8-NH2
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao

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