Anticancer agent 53
Modify Date: 2024-01-24 19:27:01
Anticancer agent 53 structure
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Common Name | Anticancer agent 53 | ||
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| CAS Number | 1926985-18-3 | Molecular Weight | 600.62 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C31H25FN4O6S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Anticancer agent 53Anticancer agent 53 is a potent anticancer agent. Anticancer agent 53 shows in vitro cytotoxicity. Anticancer agent 53 induces apoptosis and cell cycle arrest in S/G2/M phases. Anticancer agent 53 shows antitumor activity with no apparent toxicity[1]. |
| Name | Anticancer agent 53 |
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| Description | Anticancer agent 53 is a potent anticancer agent. Anticancer agent 53 shows in vitro cytotoxicity. Anticancer agent 53 induces apoptosis and cell cycle arrest in S/G2/M phases. Anticancer agent 53 shows antitumor activity with no apparent toxicity[1]. |
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| Related Catalog | |
| In Vitro | Anticancer agent 53 (compound c20) (0-1000 nM; 72 h) shows cytotoxicity with IC50s of 2.3, 42.0, 4.3, 96.3, 24.0, 47.4 nM for Hep3B, MCF7, A549, MDA-MB-231, KB, KB-vin cells, respectively[1]. Anticancer agent 53 (0.025, 0.05, 0.1 µM; 48 h) induces apoptosis and cell cycle arrest in S/G2/M phases[1]. Anticancer agent 53 (0.1. 0.2 µM; 6 h) inhibits topoisomerase I activity in A549 cells[1]. Cell Cycle Analysis[1] Cell Line: A549 cells Concentration: 0.025, 0.05, 0.1 µM Incubation Time: 0-48 h Result: Induced cell cycle arrest in S/G2/M phases. Apoptosis Analysis[1] Cell Line: A549 cells Concentration: 0.025, 0.05, 0.1 µM Incubation Time: 0-48 h Result: Induced apoptosis with the proapoptotic protein Caspase-3 and Bax were up-regulated and anti-apoptotic Bcl-2 was down-regulated. |
| In Vivo | Anticancer agent 53 (5, 25 and 50 mg/kg; IP) shows no apparent toxicity to mouse liver, kidney and hemopoietic system[1]. Anticancer agent 53 (2 mg/kg; i.v; every other day for two weeks) shows antitumor effect in HCC mouse model[1]. Animal Model: Balb/C mice[1] Dosage: 5, 25 and 50 mg/kg (saline with 5% DMSO and 5% Cremophor EL) Administration: I.p. Result: Showed no body weight loss, no significant liver damage, no significant damage occurred in spleens and livers. Animal Model: 6-8 weeks Female BALB/c nude mice (Hep3B cells)[1] Dosage: 1, 2 mg/kg Administration: I.v., every other day for total 7 doses Result: Significantly inhibited tumor growth with an average body weight of 24 g and an average tumor volume of 3800 mm[3] at 1 mg/kg and an average body weight of 22 g and average tumor volume 2380 mm[3] at 2 mg/kg. Animal Model: 6-8 weeks FVB/N mice (HCC mouse model)[1] Dosage: 2 mg/kg Administration: I.v.; every other day for two weeks Result: Inhibited the tumor growth and reduced the liver weights, and t inhibited proliferation of HCC tissues. |
| References |
| Molecular Formula | C31H25FN4O6S |
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| Molecular Weight | 600.62 |