MELK-8a

Modify Date: 2025-08-20 10:55:40

MELK-8a Structure
MELK-8a structure
 Common Name MELK-8a
CAS Number 1922153-17-0 Molecular Weight 432.572
Density N/A Boiling Point N/A
Molecular Formula C25H32N6O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of MELK-8a


MELK-8a (NVS-MELK8a) is a highly potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor with IC50 of 2 nM. MELK-8a also inhibits Flt3 (ITD), Haspin, PDGFRα with IC50s of 0.18, 0.19, and 0.42 μM, respectively. MELK plays an essential role in regulating cell mitosis in a subset of cancer cells[1].

 Names

Name MELK-8a
Synonym More Synonyms

 MELK-8a Biological Activity

Description MELK-8a (NVS-MELK8a) is a highly potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor with IC50 of 2 nM. MELK-8a also inhibits Flt3 (ITD), Haspin, PDGFRα with IC50s of 0.18, 0.19, and 0.42 μM, respectively. MELK plays an essential role in regulating cell mitosis in a subset of cancer cells[1].
Related Catalog
References

[1]. B Barry Touré, et al. Toward the Validation of Maternal Embryonic Leucine Zipper Kinase: Discovery, Optimization of Highly Potent and Selective Inhibitors, and Preliminary Biology Insight. J Med Chem. 2016 May 26;59(10):4711-23.

 Chemical & Physical Properties

Molecular Formula C25H32N6O
Molecular Weight 432.572
Exact Mass 432.264

 Synonyms

1-methyl-4-[4-[4-[3-(piperidin-4-ylmethoxy)pyridin-4-yl]pyrazol-1-yl]phenyl]piperazine
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