MELK-8a
Modify Date: 2024-01-31 13:14:40
MELK-8a structure
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Common Name | MELK-8a | ||
|---|---|---|---|---|
| CAS Number | 1922153-17-0 | Molecular Weight | 432.572 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C25H32N6O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of MELK-8aMELK-8a (NVS-MELK8a) is a highly potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor with IC50 of 2 nM. MELK-8a also inhibits Flt3 (ITD), Haspin, PDGFRα with IC50s of 0.18, 0.19, and 0.42 μM, respectively. MELK plays an essential role in regulating cell mitosis in a subset of cancer cells[1]. |
| Name | MELK-8a |
|---|---|
| Synonym | More Synonyms |
| Description | MELK-8a (NVS-MELK8a) is a highly potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor with IC50 of 2 nM. MELK-8a also inhibits Flt3 (ITD), Haspin, PDGFRα with IC50s of 0.18, 0.19, and 0.42 μM, respectively. MELK plays an essential role in regulating cell mitosis in a subset of cancer cells[1]. |
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| Related Catalog | |
| References |
| Molecular Formula | C25H32N6O |
|---|---|
| Molecular Weight | 432.572 |
| Exact Mass | 432.264 |
| 1-methyl-4-[4-[4-[3-(piperidin-4-ylmethoxy)pyridin-4-yl]pyrazol-1-yl]phenyl]piperazine |