JAK3i
Modify Date: 2025-09-08 23:00:12
JAK3i structure
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Common Name | JAK3i | ||
|---|---|---|---|---|
| CAS Number | 1918238-72-8 | Molecular Weight | 354.34 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H15FN4O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of JAK3iJAK3i is a selective, covalent JAK3 kinase inhibitor with IC50 of 0.43 nM, shows high selectivity (>3,000-fold) against the closely related kinase domains in JAK1, JAK2, or TYK2, displays 1,300-fold, 600-fold, and 50-fold over EGFR, ITK, and BTK respectively. |
| Name | JAK3i |
|---|
| Description | JAK3i is a selective, covalent JAK3 kinase inhibitor with IC50 of 0.43 nM, shows high selectivity (>3,000-fold) against the closely related kinase domains in JAK1, JAK2, or TYK2, displays 1,300-fold, 600-fold, and 50-fold over EGFR, ITK, and BTK respectively. |
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| References | References 1. Smith GA, et al. Nat Chem Biol. 2016 May;12(5):373-9. View Related Products by Target JAK |
| Molecular Formula | C18H15FN4O3 |
|---|---|
| Molecular Weight | 354.34 |
| InChIKey | KNLROUBMVYVLGX-UHFFFAOYSA-N |
| SMILES | C=CC(=O)Nc1ccc(F)c(-c2ncnc3[nH]cc(C(=O)OCC)c23)c1 |