Ezetimibe Ketone structure
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Common Name | Ezetimibe Ketone | ||
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CAS Number | 191330-56-0 | Molecular Weight | 407.409 | |
Density | 1.325 | Boiling Point | 656.1±55.0 °C at 760 mmHg | |
Molecular Formula | C24H19F2NO3 | Melting Point | N/A | |
MSDS | N/A | Flash Point | 350.6±31.5 °C |
Use of Ezetimibe KetoneEzetimibe ketone (EZM-K) is a phase-I metabolite of Ezetimibe. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator. Ezetimibe is a potent cholesterol absorption inhibitor[1][2][3]. |
Name | (3R,4S)-1-(4-Fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-(4-hydroxyphenyl)azetidin-2-one |
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Synonym | More Synonyms |
Description | Ezetimibe ketone (EZM-K) is a phase-I metabolite of Ezetimibe. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator. Ezetimibe is a potent cholesterol absorption inhibitor[1][2][3]. |
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Related Catalog | |
Target |
NPC1L1, Nrf2[1] |
References |
Density | 1.325 |
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Boiling Point | 656.1±55.0 °C at 760 mmHg |
Molecular Formula | C24H19F2NO3 |
Molecular Weight | 407.409 |
Flash Point | 350.6±31.5 °C |
Exact Mass | 407.133301 |
PSA | 57.61000 |
LogP | 3.79 |
Vapour Pressure | 0.0±2.0 mmHg at 25°C |
Index of Refraction | 1.615 |
Hazard Codes | Xi |
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1-(4-fluorophenyl)-3(R)-[3-oxo-3-(4-fluorophenyl)-propyl]-4-(S)-(4-hydroxyphenyl)azetidin-2-one |
1-(4-fluorophenyl)-3(R)-[3-(4-fluorophenyl)-3-oxopropyl]-4(S)-(4-hydroxyphenyl)-2-azetidinone |
(3R,4S)-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxo-propyl]-4-(4-hydroxyphenyl)-2-azetidinone |
AZE016 |
(3R,4S)-1-(4-Fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-(4-hydroxyphenyl)-2-azetidinone |
(3R,4S)-1-(4-Fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-(4-hydroxyphenyl)azetidin-2-one |
1-(4-fluorophenyl)-3(R)-[3-oxo-3-(4-fluorophenyl)propyl]-4-(S)-(4-hydroxyphenyl)-2-azetidinone |
2-Azetidinone, 1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-(4-hydroxyphenyl)-, (3R,4S)- |
(3R,4S)-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-(4-hydroxyphenyl)-azetidin-2-one |
Ezetimibe Intermediate-X |
EzetiMibe Ketone |
Ezetimibe Impurity 12 |