WRG-28

Modify Date: 2024-04-03 13:37:12

WRG-28 Structure
WRG-28 structure
 Common Name WRG-28
CAS Number 1913291-02-7 Molecular Weight 410.44
Density N/A Boiling Point N/A
Molecular Formula C21H18N2O5S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of WRG-28


WRG-28 is a selective, extracellularly acting DDR2 allosteric inhibitor with an IC50 of 230 nM. WRG-28 uniquely inhibits receptor-ligand interactions via allosteric modulation of the receptor. WRG-28 inhibits tumor invasion and migration, as well as tumor-supporting roles of the stroma, and inhibits metastatic breast tumor cell colonization in the lungs by targeting DDR2[1].

 Names

Name WRG-28

 WRG-28 Biological Activity

Description WRG-28 is a selective, extracellularly acting DDR2 allosteric inhibitor with an IC50 of 230 nM. WRG-28 uniquely inhibits receptor-ligand interactions via allosteric modulation of the receptor. WRG-28 inhibits tumor invasion and migration, as well as tumor-supporting roles of the stroma, and inhibits metastatic breast tumor cell colonization in the lungs by targeting DDR2[1].
Related Catalog
Target

DDR2:230 nM (IC50)

References

[1]. Grither WR, et al. Inhibition of tumor-microenvironment interaction and tumor invasion by small-molecule allosteric inhibitor of DDR2 extracellular domain. Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):E7786-E7794.

 Chemical & Physical Properties

Molecular Formula C21H18N2O5S
Molecular Weight 410.44

 Safety Information

Hazard Codes Xi
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Chemsrc provides WRG-28(CAS#:1913291-02-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of WRG-28 are included as well.>> amp version: WRG-28

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