2-chloro Palmitic Acid
Modify Date: 2025-08-27 05:27:39
2-chloro Palmitic Acid structure
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Common Name | 2-chloro Palmitic Acid | ||
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| CAS Number | 19117-92-1 | Molecular Weight | 290.86900 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C16H31ClO2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of 2-chloro Palmitic Acid2-Chlorohexadecanoic acid, an inflammatory lipid mediator, interferes with protein palmitoylation,induces ER-stress markers, reduced the ER ATP content, and activates transcription and secretion of IL-6 as well as IL-8.2-Chlorohexadecanoic acid disrupts the mitochondrial membrane potential and induces procaspase-3 and PARP cleavage.2-Chlorohexadecanoic acid can across blood-brain barrier (BBB) and compromises ER- and mitochondrial functions in the human brain endothelial cell line hCMEC/D3[1]. |
| Name | 2-chlorohexadecanoic acid |
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| Synonym | More Synonyms |
| Description | 2-Chlorohexadecanoic acid, an inflammatory lipid mediator, interferes with protein palmitoylation,induces ER-stress markers, reduced the ER ATP content, and activates transcription and secretion of IL-6 as well as IL-8.2-Chlorohexadecanoic acid disrupts the mitochondrial membrane potential and induces procaspase-3 and PARP cleavage.2-Chlorohexadecanoic acid can across blood-brain barrier (BBB) and compromises ER- and mitochondrial functions in the human brain endothelial cell line hCMEC/D3[1]. |
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| Related Catalog | |
| In Vitro | 2-Chlorohexadecanoic acid (2-ClHA; 10 μM; 4, 6 h) results phosphorylation of eIF2α starting 4 h post treatment, while total eIF2α levels remained unchanged incubation of hCMEC/D3 cells. 2-Chlorohexadecanoic acid increases expression of ATF4, a target gene of eIF2α[1]. 2-Chlorohexadecanoic acid (25 µM, 30 min) induces a decrease in the FRET ratio signal of ERAT by 40%, indicating significantly diminished [ATP]ER in cells that were treated with 2-Chlorohexadecanoic acid[1]. |
| References |
| Molecular Formula | C16H31ClO2 |
|---|---|
| Molecular Weight | 290.86900 |
| Exact Mass | 290.20100 |
| PSA | 37.30000 |
| LogP | 5.76960 |
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2-chloro Palmit... CAS#:19117-92-1 |
| Literature: Kirin Beer Kabushiki Kaisha Patent: US5461036 A1, 1995 ; |
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2-chloro Palmit... CAS#:19117-92-1 |
| Literature: Stevens, Christian; De Buyck, Laurent; De Kimpe, Norbert Tetrahedron Letters, 1998 , vol. 39, # 47 p. 8739 - 8742 |
| Hexadecanoic acid,2-chloro |
| 2-chloro-palmitic acid |
| palmitoyl acid chloride |