AG-1557

Modify Date: 2024-01-04 08:34:41

AG-1557 Structure
AG-1557 structure
Common Name AG-1557
CAS Number 189290-58-2 Molecular Weight 407.206
Density 1.7±0.1 g/cm3 Boiling Point 492.9±45.0 °C at 760 mmHg
Molecular Formula C16H14IN3O2 Melting Point N/A
MSDS N/A Flash Point 251.9±28.7 °C

 Use of AG-1557


AG-1557, compound 22 (T), is a ATP competitive inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase with a pIC50 value of 8.194[1].

 Names

Name 4-(3'-iodophenyl)-amino-6,7-dimethoxyquinazoline
Synonym More Synonyms

 AG-1557 Biological Activity

Description AG-1557, compound 22 (T), is a ATP competitive inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase with a pIC50 value of 8.194[1].
Related Catalog
References

[1]. Akshada Joshi, et al. Identification of Potential Novel EGFR Inhibitors using a Combination of Pharmacophore and Docking Methods. International Journal of Pharmacy and Pharmaceutical Sciences, ISSN- 0975-1491 Vol 7, Issue 6, 2015

 Chemical & Physical Properties

Density 1.7±0.1 g/cm3
Boiling Point 492.9±45.0 °C at 760 mmHg
Molecular Formula C16H14IN3O2
Molecular Weight 407.206
Flash Point 251.9±28.7 °C
Exact Mass 407.013062
PSA 56.27000
LogP 4.34
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.708
Storage condition -20℃

 Synonyms

N-(3-Iodophenyl)-6,7-dimethoxy-4-quinazolinamine
ag-1557
4-quinazolinamine, N-(3-iodophenyl)-6,7-dimethoxy-
N-(3-iodophenyl)-6,7-dimethoxyquinazolin-4-amine