Lapaquistat Acetate
Modify Date: 2025-08-26 12:27:02
Lapaquistat Acetate structure
|
Common Name | Lapaquistat Acetate | ||
|---|---|---|---|---|
| CAS Number | 189060-13-7 | Molecular Weight | 645.14000 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C33H41ClN2O9 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Lapaquistat AcetateLapaquistat acetate (TAK-475) is a squalene synthase inhibitor, blocking the conversion of farnesyl diphosphate (FPP) to squalene[1]. Lapaquistat acetate (TAK-475) is originally intended use to Mevalonate Kinase Deficiency (MKD), it is effective at lowering low-density lipoprotein cholesterol, but it might cause liver damage[2]. |
| Name | 2-[1-[2-[(3R,5S)-1-(3-acetyloxy-2,2-dimethylpropyl)-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-5H-4,1-benzoxazepin-3-yl]acetyl]piperidin-4-yl]acetic acid |
|---|---|
| Synonym | More Synonyms |
| Description | Lapaquistat acetate (TAK-475) is a squalene synthase inhibitor, blocking the conversion of farnesyl diphosphate (FPP) to squalene[1]. Lapaquistat acetate (TAK-475) is originally intended use to Mevalonate Kinase Deficiency (MKD), it is effective at lowering low-density lipoprotein cholesterol, but it might cause liver damage[2]. |
|---|---|
| Related Catalog | |
| Target |
Squalene synthase[1] |
| References |
| Molecular Formula | C33H41ClN2O9 |
|---|---|
| Molecular Weight | 645.14000 |
| Exact Mass | 644.25000 |
| PSA | 131.91000 |
| LogP | 4.87400 |
| InChIKey | CMLUGNQVANVZHY-POURPWNDSA-N |
| SMILES | COc1cccc(C2OC(CC(=O)N3CCC(CC(=O)O)CC3)C(=O)N(CC(C)(C)COC(C)=O)c3ccc(Cl)cc32)c1OC |
| Lapaquistat acetate |
| UNII-IUH3AY74O3 |
| TAK-475 |