Lapaquistat
Modify Date: 2024-01-30 13:03:36
Lapaquistat structure
|
Common Name | Lapaquistat | ||
|---|---|---|---|---|
| CAS Number | 189059-71-0 | Molecular Weight | 603.10300 | |
| Density | 1.261g/cm3 | Boiling Point | 824.024ºC at 760 mmHg | |
| Molecular Formula | C31H39ClN2O8 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 452.154ºC | |
Use of LapaquistatLapaquistat (T-91485), a cholesterol biosynthesis inhibitor, is the active metabolite of TAK-475. Lapaquistat can decrease statin-induced myotoxicity in lipid-lowering therapy[1]. |
| Name | 2-[1-[2-[(3R)-7-chloro-5-(2,3-dimethoxyphenyl)-1-(3-hydroxy-2,2-dimethylpropyl)-2-oxo-5H-4,1-benzoxazepin-3-yl]acetyl]piperidin-4-yl]acetic acid |
|---|---|
| Synonym | More Synonyms |
| Description | Lapaquistat (T-91485), a cholesterol biosynthesis inhibitor, is the active metabolite of TAK-475. Lapaquistat can decrease statin-induced myotoxicity in lipid-lowering therapy[1]. |
|---|---|
| Related Catalog | |
| Target |
Cholesterol biosynthesis[1] |
| References |
| Density | 1.261g/cm3 |
|---|---|
| Boiling Point | 824.024ºC at 760 mmHg |
| Molecular Formula | C31H39ClN2O8 |
| Molecular Weight | 603.10300 |
| Flash Point | 452.154ºC |
| Exact Mass | 602.23900 |
| PSA | 125.84000 |
| LogP | 4.30320 |
| Vapour Pressure | 0mmHg at 25°C |
| Index of Refraction | 1.565 |
| Lapaquistat [INN] |
| N-[[(3R,5S)-1-(3-hydroxy-2,2-dimethylpropyl)-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]acetyl]piperidine-4-acetic acid |
| N-[[(3R,5S)-7-chloro-5-(2,3-dimethoxyphenyl)-1-(3-hydroxy-2,2-dimethylpropyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]acetyl]piperidine-4-acetic acid |
| 4-Piperidineacetic acid,1-(((3R,5S)-1-(3-(hydroxy)-2,2-dimethylpropyl)-7-chloro-5-(2,3-dimethoxyphenyl)-1,2,3,5-tetrahydro-2-oxo-4,1-benzoxazepin-3-yl)acetyl) |
| UNII-PEZ79BV72X |
| N-[[(3R,5S)-1-(3-hydroxy-2,2-dimethylpropyl)-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]acetyl]piperidin-4-acetic acid |
| 2-(1-(2-((3R,5S)-1-(3-hydroxy-2,2-dimethylpropyl)-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-1,2,3,5-tetrahydrobenzo(E)(1,4)oxazepin-3-yl)acetyl)piperidin-4-yl)acetic acid |
| lapaquistat |
| N-[(3R,5S)-7-chloro-5-(2,3-dimethoxyphenyl)-1-(3-hydroxy-2,2-dimethylpropyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepine-3-acetyl]piperidine-4-acetic acid |