TAK-828F
Modify Date: 2024-01-10 23:15:55
TAK-828F structure
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Common Name | TAK-828F | ||
|---|---|---|---|---|
| CAS Number | 1854901-94-2 | Molecular Weight | 509.57 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C28H32FN3O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of TAK-828FTAK-828F is a potent, selective, and orally available retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonist (binding IC50=1.9 nM, reporter gene IC50=6.1 nM). TAK-828F shows excellent ROR isoforms selectivity (>5000-fold selectivity against human RORα and RORβ)[1]. |
| Name | TAK-828F |
|---|
| Description | TAK-828F is a potent, selective, and orally available retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonist (binding IC50=1.9 nM, reporter gene IC50=6.1 nM). TAK-828F shows excellent ROR isoforms selectivity (>5000-fold selectivity against human RORα and RORβ)[1]. |
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| Related Catalog | |
| Target |
IC50: 1.9 nM (RORγt, binding IC50), 6.1 nM (RORγt, reporter gene IC50)[1] |
| References |
| Molecular Formula | C28H32FN3O5 |
|---|---|
| Molecular Weight | 509.57 |
| InChIKey | ICMFYVOUDGRBLG-NJMNTPMDSA-N |
| SMILES | COc1ccc2c(n1)CCN(C(=O)C1CC(CC(=O)O)C1)C2C(=O)Nc1cc(F)c2c(c1)CCC2(C)C |