SirReal2
Modify Date: 2025-08-22 14:19:59
SirReal2 structure
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Common Name | SirReal2 | ||
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| CAS Number | 1848251-24-0 | Molecular Weight | 420.549 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H20N4OS2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SirReal2SirReal2 (MZ25) is a novel potent, selective Sirt2 inhibitor with IC50 of 0.435 uM; displays >1,000-fold more potently than Sirt1, Sirt3, Sirt4, Sirt5 and Sirt6; increases α-tubulin acetylation in HeLa cells, significantly results in a dose-dependent depletion of BubR1. |
| Name | SirReal2 |
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| Description | SirReal2 (MZ25) is a novel potent, selective Sirt2 inhibitor with IC50 of 0.435 uM; displays >1,000-fold more potently than Sirt1, Sirt3, Sirt4, Sirt5 and Sirt6; increases α-tubulin acetylation in HeLa cells, significantly results in a dose-dependent depletion of BubR1. |
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| References | References 1. Rumpf T, et al. Nat Commun. 2015 Feb 12;6:6263. 2. Schiedel M, et al. Angew Chem Int Ed Engl. 2016 Feb 5;55(6):2252-6. View Related Products by Target Sirtuin |
| Molecular Formula | C22H20N4OS2 |
|---|---|
| Molecular Weight | 420.549 |