709002-46-0

709002-46-0 structure

Name: SirReal 2
Chemical Name: SirReal2
CAS Number: 709002-46-0
Molecular Formula: C₂₂H₂₀N₄OS₂
Molecular Weight: 420.550
Catalog: Signaling Pathways Cell Cycle/DNA Damage Sirtuin
Create Date: 2016-08-23 21:47:29
Modify Date: 2025-08-23 19:57:32
SirReal2 is a potent, isotype-selective Sirt2 inhibitor with an IC50 value of 140 nM and has very little effect on the activities of Sirt3-5. SirReal2 leads to tubulin hyperacetylation in HeLa cells and induces destabilization of the checkpoint protein BubR1[1].

Name	SirReal2
Synonyms	2-[(4,6-Dimethylpyrimidin-2-yl)sulfanyl]-N-[5-(1-naphthylmethyl)-1,3-thiazol-2-yl]acetamide Acetamide, 2-[(4,6-dimethyl-2-pyrimidinyl)thio]-N-[5-(1-naphthalenylmethyl)-2-thiazolyl]- 2-[(4,6-Dimethyl-2-pyrimidinyl)sulfanyl]-N-[5-(1-naphthylmethyl)-1,3-thiazol-2-yl]acetamide

Description	SirReal2 is a potent, isotype-selective Sirt2 inhibitor with an IC50 value of 140 nM and has very little effect on the activities of Sirt3-5. SirReal2 leads to tubulin hyperacetylation in HeLa cells and induces destabilization of the checkpoint protein BubR1[1].
Related Catalog	Signaling Pathways >> Epigenetics >> Sirtuin Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Sirtuin
Target	SIRT2:140 nM (IC50)
References	[1]. Rumpf T, et al. Selective Sirt2 inhibition by ligand-induced rearrangement of the active site. Nat Commun. 2015 Feb 12;6:6263.

RIDADR	NONH for all modes of transport