sitaxsentan

Modify Date: 2024-01-09 04:56:02

sitaxsentan structure	Common Name	sitaxsentan
	CAS Number	184036-34-8	Molecular Weight	454.90500
	Density	1.6g/cm3	Boiling Point	600.4ºC at 760 mmHg
	Molecular Formula	C₁₈H₁₅ClN₂O₆S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	316.9ºC

Use of sitaxsentan

Sitaxsentan (IPI 1040; TBC 11251) is a selective endothelin A (ETA) receptor antagonist. Antihypertensive. Sitaxsentan is used in treatment of chronic heart failure.IC50 value:Target: ETA receptor

Name	N-(4-Chloro-3-methylisoxazol-5-yl)-2-(2-(6-methylbenzo-[d][1,3]dioxol-5-yl)acetyl)thiophene-3-sulfonamide
Synonym	More Synonyms

Description	Sitaxsentan (IPI 1040; TBC 11251) is a selective endothelin A (ETA) receptor antagonist. Antihypertensive. Sitaxsentan is used in treatment of chronic heart failure.IC50 value:Target: ETA receptor
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Endothelin Receptor Research Areas >> Cardiovascular Disease
References	[1]. Chin M, Levy RD, Yoshida EM, Byrne MF.Sitaxsentan-induced acute severe hepatitis treated with glucocorticoid therapy.Can Respir J. 2012 Jan-Feb;19(1):e1-2. [2]. Sandoval J, et al. STRIDE-4 investigators.Safety and efficacy of sitaxsentan 50 and 100 mg in patients with pulmonary arterial hypertension.Pulm Pharmacol Ther. 2012 Feb;25(1):33-9. Epub 2011 Nov 2. [3]. Safdar Z. Effect of transition from sitaxsentan to ambrisentan in pulmonary arterial hypertension.Vasc Health Risk Manag. 2011;7:119-24. Epub 2011 Mar 2. [4]. Rondelet B, et al. Sildenafil added to sitaxsentan in overcirculation-induced pulmonary arterial hypertension.Am J Physiol Heart Circ Physiol. 2010 Oct;299(4):H1118-23. Epub 2010 Aug 6. [5]. Kaehler, et al. Successful treatment of portopulmonary hypertension with the selective endothelin receptor antagonist Sitaxentan. Wien Klin Wochenschr. 2011 Apr;123(7-8):248-52. Epub 2011 Mar 31.

Description

Sitaxsentan (IPI 1040; TBC 11251) is a selective endothelin A (ETA) receptor antagonist. Antihypertensive. Sitaxsentan is used in treatment of chronic heart failure.IC50 value:Target: ETA receptor

Related Catalog

Signaling Pathways >> GPCR/G Protein >> Endothelin Receptor

Research Areas >> Cardiovascular Disease

References

[1]. Chin M, Levy RD, Yoshida EM, Byrne MF.Sitaxsentan-induced acute severe hepatitis treated with glucocorticoid therapy.Can Respir J. 2012 Jan-Feb;19(1):e1-2.

[2]. Sandoval J, et al. STRIDE-4 investigators.Safety and efficacy of sitaxsentan 50 and 100 mg in patients with pulmonary arterial hypertension.Pulm Pharmacol Ther. 2012 Feb;25(1):33-9. Epub 2011 Nov 2.

[3]. Safdar Z. Effect of transition from sitaxsentan to ambrisentan in pulmonary arterial hypertension.Vasc Health Risk Manag. 2011;7:119-24. Epub 2011 Mar 2.

[4]. Rondelet B, et al. Sildenafil added to sitaxsentan in overcirculation-induced pulmonary arterial hypertension.Am J Physiol Heart Circ Physiol. 2010 Oct;299(4):H1118-23. Epub 2010 Aug 6.

[5]. Kaehler, et al. Successful treatment of portopulmonary hypertension with the selective endothelin receptor antagonist Sitaxentan. Wien Klin Wochenschr. 2011 Apr;123(7-8):248-52. Epub 2011 Mar 31.

Density	1.6g/cm3
Boiling Point	600.4ºC at 760 mmHg
Molecular Formula	C₁₈H₁₅ClN₂O₆S₂
Molecular Weight	454.90500
Flash Point	316.9ºC
Exact Mass	454.00600
PSA	144.35000
LogP	5.11500
Vapour Pressure	2.25E-14mmHg at 25°C
Index of Refraction	1.687
Storage condition	2-8℃

N/A

CAS#:1008726-80-4

3-(N-(4-CHLORO-...

CAS#:210421-71-9

sitaxsentan

CAS#:184036-34-8

Literature: Wu, Chengde; Chan, Ming F.; Stavros, Fiona; Raju; Okun, Ilya; Mong, Seymour; Keller, Karin M.; Brock, Tommy; Kogan, Timothy P.; Dixon, Richard A. F. Journal of Medicinal Chemistry, 1997 , vol. 40, # 11 p. 1690 - 1697

5-(Chloromethyl...

CAS#:117661-72-0

~69%

sitaxsentan

CAS#:184036-34-8

Literature: Texas Biotechnology Corporation Patent: US6432994 B1, 2002 ; US 6432994 B1

5-(Chloromethyl...

CAS#:117661-72-0

3-(N-(4-CHLORO-...

CAS#:210421-71-9

sitaxsentan

CAS#:184036-34-8

Literature: Chen, Jinling; Koppenol, Sandy; Rajewski, Lian; Trammel, Andrew; Amsberry, Kent; Schoeneman, Aaron Patent: US2008/76812 A1, 2008 ; Location in patent: Page/Page column 10 ;

5-(Chloromethyl...

CAS#:20850-43-5

5-(Chloromethyl...

CAS#:117661-72-0

3-(N-(4-CHLORO-...

CAS#:210421-71-9

sitaxsentan

CAS#:184036-34-8

Literature: ENCYSIVE PHARMACEUTICALS, INC. Patent: WO2007/106494 A2, 2007 ; Location in patent: Page/Page column 39-40 ;

3-(N-(4-CHLORO-...

CAS#:210421-71-9

sitaxsentan

CAS#:184036-34-8

Literature: Given, Bruce D.; Dixon, Richard A.F. Patent: US2008/85313 A1, 2008 ; Location in patent: Page/Page column 15 ;

5-(Chloromethyl...

CAS#:117661-72-0

3-(N-(4-CHLORO-...

CAS#:184040-74-2

~73%

sitaxsentan

CAS#:184036-34-8

Literature: Texas Biotechnology Corp. Patent: US6342610 B2, 2002 ; Location in patent: Page column 126 ; US 6342610 B2

Precursor 4
CAS#:210421-71-9 3-(N-(4-CHLORO-... CAS#:117661-72-0 5-(Chloromethyl... CAS#:20850-43-5 5-(Chloromethyl... CAS#:184040-74-2 3-(N-(4-CHLORO-...
DownStream 0

Sitaxsentan

Sitax

DC Chemicals Limited
China
Product Name: Sitaxsentan
Price: $Inquiry/250mg $Inquiry/1g $600.0/100mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: N-(4-CHLORO-3-METHYLISOXAZOL-5-YL)-2-(2-(6-METHYLBENZO[D][1,3]DIOXOL-5-YL)ACETYL)THIOPHENE-3-SULFONAMIDE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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sitaxsentan

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