184036-34-8
184036-34-8 structure
- Name: sitaxsentan
- Chemical Name: N-(4-Chloro-3-methylisoxazol-5-yl)-2-(2-(6-methylbenzo-[d][1,3]dioxol-5-yl)acetyl)thiophene-3-sulfonamide
- CAS Number: 184036-34-8
- Molecular Formula: C18H15ClN2O6S2
- Molecular Weight: 454.90500
- Catalog: Signaling Pathways GPCR/G Protein Endothelin Receptor
- Create Date: 2019-01-09 19:41:50
- Modify Date: 2025-08-26 23:12:55
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Sitaxsentan (IPI 1040; TBC 11251) is a selective endothelin A (ETA) receptor antagonist. Antihypertensive. Sitaxsentan is used in treatment of chronic heart failure.IC50 value:Target: ETA receptor
| Name | N-(4-Chloro-3-methylisoxazol-5-yl)-2-(2-(6-methylbenzo-[d][1,3]dioxol-5-yl)acetyl)thiophene-3-sulfonamide |
|---|---|
| Synonyms |
Sitaxsentan
Sitax |
| Description | Sitaxsentan (IPI 1040; TBC 11251) is a selective endothelin A (ETA) receptor antagonist. Antihypertensive. Sitaxsentan is used in treatment of chronic heart failure.IC50 value:Target: ETA receptor |
|---|---|
| Related Catalog | |
| References |
| Density | 1.6g/cm3 |
|---|---|
| Boiling Point | 600.4ºC at 760 mmHg |
| Molecular Formula | C18H15ClN2O6S2 |
| Molecular Weight | 454.90500 |
| Flash Point | 316.9ºC |
| Exact Mass | 454.00600 |
| PSA | 144.35000 |
| LogP | 5.11500 |
| Vapour Pressure | 2.25E-14mmHg at 25°C |
| Index of Refraction | 1.687 |
| Storage condition | 2-8℃ |
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~%
184036-34-8 |
| Literature: Wu, Chengde; Chan, Ming F.; Stavros, Fiona; Raju; Okun, Ilya; Mong, Seymour; Keller, Karin M.; Brock, Tommy; Kogan, Timothy P.; Dixon, Richard A. F. Journal of Medicinal Chemistry, 1997 , vol. 40, # 11 p. 1690 - 1697 |
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~69%
184036-34-8 |
| Literature: Texas Biotechnology Corporation Patent: US6432994 B1, 2002 ; US 6432994 B1 |
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~%
184036-34-8 |
| Literature: Chen, Jinling; Koppenol, Sandy; Rajewski, Lian; Trammel, Andrew; Amsberry, Kent; Schoeneman, Aaron Patent: US2008/76812 A1, 2008 ; Location in patent: Page/Page column 10 ; |
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~%
184036-34-8 |
| Literature: ENCYSIVE PHARMACEUTICALS, INC. Patent: WO2007/106494 A2, 2007 ; Location in patent: Page/Page column 39-40 ; |
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~%
184036-34-8 |
| Literature: Given, Bruce D.; Dixon, Richard A.F. Patent: US2008/85313 A1, 2008 ; Location in patent: Page/Page column 15 ; |
|
~73%
184036-34-8 |
| Literature: Texas Biotechnology Corp. Patent: US6342610 B2, 2002 ; Location in patent: Page column 126 ; US 6342610 B2 |
| Precursor 4 | |
|---|---|
| DownStream 0 | |