Tat-NR2B9c TFA

Modify Date: 2025-08-26 21:09:24

Tat-NR2B9c TFA structure	Common Name	Tat-NR2B9c TFA
	CAS Number	1834571-04-8	Molecular Weight	2632.90
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₀₇H₁₈₉F₃N₄₂O₃₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Tat-NR2B9c TFA

Tat-NR2B9c (TFA) is a 20-aa peptide, which acts as a postsynaptic density-95 (PSD-95) inhibitor, with an EC50 of 6.7 nM for PSD-95d2 (PSD-95 PDZ domain 2), and 670 nM for PSD-95d1[1]. Tat-NR2B9c also reduces NMDA-induced p38 activation, and possesses neuroprotective efficacy[2].

Name	Tat-NR2B9c TFA

Description	Tat-NR2B9c (TFA) is a 20-aa peptide, which acts as a postsynaptic density-95 (PSD-95) inhibitor, with an EC50 of 6.7 nM for PSD-95d2 (PSD-95 PDZ domain 2), and 670 nM for PSD-95d1[1]. Tat-NR2B9c also reduces NMDA-induced p38 activation, and possesses neuroprotective efficacy[2].
Related Catalog	Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK Research Areas >> Neurological Disease
Target	EC50: 6.7 nM (PSD-95d2), 670 nM (PSD-95d1)[1] p38[2]
References	[1]. Cui H, et al. PDZ protein interactions underlying NMDA receptor-mediated excitotoxicity and neuroprotection by PSD-95 inhibitors. J Neurosci. 2007 Sep 12;27(37):9901-15. [2]. Fan J, et al. P38 MAPK is involved in enhanced NMDA receptor-dependent excitotoxicity in YAC transgenic mouse model of Huntington disease. Neurobiol Dis. 2012 Mar;45(3):999-1009.

Molecular Formula	C₁₀₇H₁₈₉F₃N₄₂O₃₂
Molecular Weight	2632.90
InChIKey	ZTLUQAFFPNSALN-OFWLNFCRSA-N
SMILES	CCC(C)C(NC(=O)C(CO)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCCN)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCC(N)=O)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)C(CCCNC(=N)N)NC(=O)CNC(=O)C(N)Cc1ccc(O)cc1)C(=O)NC(CCC(=O)O)C(=O)NC(CO)C(=O)NC(CC(=O)O)C(=O)NC(C(=O)O)C(C)C.O=C(O)C(F)(F)F
Storage condition	2-8℃

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Shanghai Nianxing Industrial Co., Ltd
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Product Name: Tat-NR2B9cTFA
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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.