ML378
Modify Date: 2025-08-25 22:57:20
ML378 structure
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Common Name | ML378 | ||
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| CAS Number | 1831135-21-7 | Molecular Weight | 534.01 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C25H32ClN5O6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ML378ML378 (CID71710938;JJH-254) is an in vivo active carbamate-based dual inhibitor of lysophospholipase LYPLA1 (APT1) and LYPLA2 (APT2) with IC50 of 122 nM and 245 nM, repectively; also inhibits ABHD6 with IC50 of 3.15 nM, and displays 13-fold and >40-fold selectivity over FAAH and 20SHs respectively. |
| Name | ML378 |
|---|
| Description | ML378 (CID71710938;JJH-254) is an in vivo active carbamate-based dual inhibitor of lysophospholipase LYPLA1 (APT1) and LYPLA2 (APT2) with IC50 of 122 nM and 245 nM, repectively; also inhibits ABHD6 with IC50 of 3.15 nM, and displays 13-fold and >40-fold selectivity over FAAH and 20SHs respectively. |
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| References | References 1. Hulce JJ, et al. Probe Reports from the NIH Molecular Libraries Program [Internet]. View Related Products by Target Phospholipase |
| Molecular Formula | C25H32ClN5O6 |
|---|---|
| Molecular Weight | 534.01 |
| InChIKey | KQQSWNNGVFWIEL-UHFFFAOYSA-N |
| SMILES | O=C(ON1C(=O)C2CN(C(=O)N3CCOCC3)CCN2C1=O)N1CCC(CCc2ccc(Cl)cc2)CC1 |