1831135-21-7
1831135-21-7 structure
- Name: ML378
- Chemical Name: ML378
- CAS Number: 1831135-21-7
- Molecular Formula: C25H32ClN5O6
- Molecular Weight: 534.01
- Create Date: 2020-01-11 16:54:51
- Modify Date: 2025-08-25 22:57:20
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ML378 (CID71710938;JJH-254) is an in vivo active carbamate-based dual inhibitor of lysophospholipase LYPLA1 (APT1) and LYPLA2 (APT2) with IC50 of 122 nM and 245 nM, repectively; also inhibits ABHD6 with IC50 of 3.15 nM, and displays 13-fold and >40-fold selectivity over FAAH and 20SHs respectively.
| Name | ML378 |
|---|
| Description | ML378 (CID71710938;JJH-254) is an in vivo active carbamate-based dual inhibitor of lysophospholipase LYPLA1 (APT1) and LYPLA2 (APT2) with IC50 of 122 nM and 245 nM, repectively; also inhibits ABHD6 with IC50 of 3.15 nM, and displays 13-fold and >40-fold selectivity over FAAH and 20SHs respectively. |
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| References | References 1. Hulce JJ, et al. Probe Reports from the NIH Molecular Libraries Program [Internet]. View Related Products by Target Phospholipase |
| Molecular Formula | C25H32ClN5O6 |
|---|---|
| Molecular Weight | 534.01 |