Valepotriate

Modify Date: 2024-01-02 22:53:32

Valepotriate structure	Common Name	Valepotriate
	CAS Number	18296-44-1	Molecular Weight	422.469
	Density	1.2±0.1 g/cm3	Boiling Point	525.9±50.0 °C at 760 mmHg
	Molecular Formula	C₂₂H₃₀O₈	Melting Point	N/A
	MSDS	N/A	Flash Point	226.5±30.2 °C

Use of Valepotriate

Valepotriate, isolated from Valeriana jatamansi Jones, has anti-epileptic and anti-cancer activities[1][2].

Name	Valtrate
Synonym	More Synonyms

Description	Valepotriate, isolated from Valeriana jatamansi Jones, has anti-epileptic and anti-cancer activities[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vivo	Valepotriate showed significant anti-epileptic activity against MES- and PTZ-induced epilepsy at doses of 5, 10, and 20 mg/kg, and ED50 values for MES- and PTZ-induced epilepsy were 7.84 and 7.19 mg/kg, respectively. Furthermore, valepotriate (10 and 20 mg/kg) can significantly prolong sleeping time and shorten the latency time on the pentobarbital sodium-induced sleeping time test. Furthermore, valepotriate (5, 10, and 20 mg/kg) could significantly up-regulate the expression of GABAA, GAD65, and Bcl-2 and down-regulate the expression of caspase-3, but had no significant effect on the expression of GABAB[2].
References	[1]. Yan YY, et al. A novel derivative of valepotriate inhibits the PI3K/AKT pathway and causes Noxa-dependent apoptosis in human pancreatic cancer cells. Acta Pharmacol Sin. 2020 Feb 11. [2]. Wu A, et al. Anti-epileptic Effects of Valepotriate Isolated from Valeriana jatamansi Jones and Its Possible Mechanisms. Pharmacogn Mag. 2017 Jul-Sep;13(51):512-516.

Density	1.2±0.1 g/cm3
Boiling Point	525.9±50.0 °C at 760 mmHg
Molecular Formula	C₂₂H₃₀O₈
Molecular Weight	422.469
Flash Point	226.5±30.2 °C
Exact Mass	422.194061
PSA	100.66000
LogP	2.36
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.528

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EK7902000

CHEMICAL NAME :: Butanoic acid, 3-methyl-, 4-((acetyloxy)methyl)-6,7a-dihydrospiro(cyclopenta(c) pyran- 7(1H),2'-oxirane)-1,6-diyl ester, (1S-(1-alpha,6-alpha,7-beta,7a-alpha))-

CAS REGISTRY NUMBER :: 18296-44-1

LAST UPDATED :: 198809

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C22-H30-O8

MOLECULAR WEIGHT :: 422.52

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 60 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Bacteria - Escherichia coli

DOSE/DURATION :: 50 nmol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 203,81,1988

HS Code	29329990

Precursor 0
DownStream 1
CAS#:18234-46-3 Baldrinal

Butanoic acid, 3-methyl-, (1S,6S,7R,7aS)-4-[(acetyloxy)methyl]-6,7a-dihydrospiro[cyclopenta[c]pyran-7(1H),2'-oxirane]-1,6-diyl ester

(1S,6S,7R,7aS)-4-(Acetoxymethyl)-6,7a-dihydro-1H-spiro[cyclopenta[c]pyran-7,2'-oxirane]-1,6-diyl bis(3-methylbutanoate)

tolterodine

Baldrisedon

(1S-(1a,6a,7b,7aa))-3-Methylbutanoic Acid 4-((Acetyloxy)methyl)-6,7a-dihydrospiro(cyclopenta[c]pyran-7(1H),2'-oxirane)-1,6-diyl Ester

(1S,6S,7R,7aS)-4-[(acetyloxy)methyl]-6,7a-dihydro-1H-spiro[cyclopenta[c]pyran-7,2'-oxirane]-1,6-diyl bis(3-methylbutanoate)

valepotriate

ValtratuM

Halazuchrome B

ValepotriatuM

EINECS 242-174-2

BioBioPha
China
Product Name: Valepotriate
Price: ￥Inquiry/10mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Xueping-Zheng

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Valepotriate
Price: ￥1768.0/20mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Valtrate
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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Price: ￥1980/5 mg

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Valepotriate

Use of Valepotriate

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Valepotriate Biological Activity

Chemical & Physical Properties

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

Safety Information

Precursor & DownStream

Synonyms