DMU2139(CYP1B1 inhibitor 6j)

Modify Date: 2024-01-16 08:26:53

DMU2139(CYP1B1 inhibitor 6j) structure	Common Name	DMU2139(CYP1B1 inhibitor 6j)
	CAS Number	1821143-80-9	Molecular Weight	289.33
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₉H₁₅NO₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of DMU2139(CYP1B1 inhibitor 6j)

DMU2139 is a potent and specific CYP1B1 inhibitor, with IC50s of 9 nM and 795 nM for CYP1B1 and CYP1A1, respectively.

Name	DMU2139

Description	DMU2139 is a potent and specific CYP1B1 inhibitor, with IC50s of 9 nM and 795 nM for CYP1B1 and CYP1A1, respectively.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450 Research Areas >> Cancer
Target	CYP1B1:9 nM (IC50) CYP1A1:795 nM (IC50)
In Vitro	DMU2139 (6j) shows 88 and 133-fold selectivity for CYP1B1 over CYP1A1 and CYP1A2. In the presence of DMU2139, the EC50 is reversed back to 8.3 μM from 61 μM (seen in CYP1B1-expressing cells without any inhibitor). The EC50 value, in the presence of DMU2139, resembles the EC50 of cisplatin, 8.7μM, in cells transfected with the empty plasmid which has no CYP1B1 gene and therefore cannot express CYP1B1 protein[1].
References	[1]. Horley NJ, et al. Discovery and characterization of novel CYP1B1 inhibitors based on heterocyclic chalcones: Overcoming cisplatin resistance in CYP1B1-overexpressing lines. Eur J Med Chem. 2017 Mar 31;129:159-174.

Molecular Formula	C₁₉H₁₅NO₂
Molecular Weight	289.33
Storage condition	2-8℃

DC Chemicals Limited
China
Product Name: DMU2139(CYP1B1 inhibitor 6j)
Price: $650.0/100mg $1000.0/250mg $1900.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Get all suppliers and price by the below link:

DMU2139(CYP1B1 inhibitor 6j) suppliers

Price: ￥1650/10 mM * 1 mL in DMSO

Reference only. check more DMU2139(CYP1B1 inhibitor 6j) price