CU-3
Modify Date: 2025-08-26 21:19:33
CU-3 structure
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Common Name | CU-3 | ||
|---|---|---|---|---|
| CAS Number | 1815598-71-0 | Molecular Weight | 392.47 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C16H12N2O4S3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CU-3(5Z,2E)-CU-3 is a potent and selective inhibitor against the α-isozyme of DGK with an IC50 value of 0.6 μM, competitively inhibits the affinity of DGKα for ATP with a Km value of 0.48 mM. (5Z,2E)-CU-3 targets the catalytic region, but not the regulatory region of DGKα. (5Z,2E)-CU-3 has antitumoral and proimmunogenic effects, enhances the apoptosis of cancer cells and the activation of T cells[1]. |
| Name | (5Z,2E)-CU-3 |
|---|
| Description | (5Z,2E)-CU-3 is a potent and selective inhibitor against the α-isozyme of DGK with an IC50 value of 0.6 μM, competitively inhibits the affinity of DGKα for ATP with a Km value of 0.48 mM. (5Z,2E)-CU-3 targets the catalytic region, but not the regulatory region of DGKα. (5Z,2E)-CU-3 has antitumoral and proimmunogenic effects, enhances the apoptosis of cancer cells and the activation of T cells[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 0.6 μM (DGKα)[1] |
| References |
| Molecular Formula | C16H12N2O4S3 |
|---|---|
| Molecular Weight | 392.47 |
| InChIKey | YIUMXULORVBWLL-SPGDJUBISA-N |
| SMILES | O=C1C(=CC=Cc2ccco2)SC(=S)N1NS(=O)(=O)c1ccccc1 |