CU-3

Modify Date: 2024-01-15 12:26:54

CU-3 structure	Common Name	CU-3
	CAS Number	1815598-71-0	Molecular Weight	392.47
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₆H₁₂N₂O₄S₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of CU-3

(5Z,2E)-CU-3 is a potent and selective inhibitor against the α-isozyme of DGK with an IC50 value of 0.6 μM, competitively inhibits the affinity of DGKα for ATP with a Km value of 0.48 mM. (5Z,2E)-CU-3 targets the catalytic region, but not the regulatory region of DGKα. (5Z,2E)-CU-3 has antitumoral and proimmunogenic effects, enhances the apoptosis of cancer cells and the activation of T cells[1].

Name	(5Z,2E)-CU-3

Description	(5Z,2E)-CU-3 is a potent and selective inhibitor against the α-isozyme of DGK with an IC50 value of 0.6 μM, competitively inhibits the affinity of DGKα for ATP with a Km value of 0.48 mM. (5Z,2E)-CU-3 targets the catalytic region, but not the regulatory region of DGKα. (5Z,2E)-CU-3 has antitumoral and proimmunogenic effects, enhances the apoptosis of cancer cells and the activation of T cells[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
Target	IC50: 0.6 μM (DGKα)[1]
References	[1]. Liu K, et al. A novel diacylglycerol kinase α-selective inhibitor, CU-3, induces cancer cell apoptosis and enhances immune response. J Lipid Res. 2016 Mar;57(3):368-79.

Molecular Formula	C₁₆H₁₂N₂O₄S₃
Molecular Weight	392.47

DC Chemicals Limited
China
Product Name: CU-3
Price: $600.0/100mg $1200.0/250mg $2400.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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