1815598-71-0

1815598-71-0 structure

Name: CU-3
Chemical Name: (5Z,2E)-CU-3
CAS Number: 1815598-71-0
Molecular Formula: C₁₆H₁₂N₂O₄S₃
Molecular Weight: 392.47
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2019-11-02 01:44:16
Modify Date: 2024-01-15 12:26:54
(5Z,2E)-CU-3 is a potent and selective inhibitor against the α-isozyme of DGK with an IC50 value of 0.6 μM, competitively inhibits the affinity of DGKα for ATP with a Km value of 0.48 mM. (5Z,2E)-CU-3 targets the catalytic region, but not the regulatory region of DGKα. (5Z,2E)-CU-3 has antitumoral and proimmunogenic effects, enhances the apoptosis of cancer cells and the activation of T cells[1].

Name	(5Z,2E)-CU-3

Description	(5Z,2E)-CU-3 is a potent and selective inhibitor against the α-isozyme of DGK with an IC50 value of 0.6 μM, competitively inhibits the affinity of DGKα for ATP with a Km value of 0.48 mM. (5Z,2E)-CU-3 targets the catalytic region, but not the regulatory region of DGKα. (5Z,2E)-CU-3 has antitumoral and proimmunogenic effects, enhances the apoptosis of cancer cells and the activation of T cells[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
Target	IC50: 0.6 μM (DGKα)[1]
References	[1]. Liu K, et al. A novel diacylglycerol kinase α-selective inhibitor, CU-3, induces cancer cell apoptosis and enhances immune response. J Lipid Res. 2016 Mar;57(3):368-79.

Molecular Formula	C₁₆H₁₂N₂O₄S₃
Molecular Weight	392.47