EN6
Modify Date: 2025-09-18 12:20:00
EN6 structure
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Common Name | EN6 | ||
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| CAS Number | 1808714-73-9 | Molecular Weight | 368.34 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H14F2N4O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of EN6EN6 is a small-molecule in vivo activator of autophagy that covalently targets cysteine 277 in the ATP6V1A subunit of the lysosomal the vacuolar H+ ATPase (v-ATPase). EN6-mediated ATP6V1A modification decouples the v-ATPase from the Rags, leading to inhibition of mTORC1 signaling, increased lysosomal acidification and activation of autophagy. EN6 clears TDP-43 aggregates, a causative agent in frontotemporal dementia, in a lysosome-dependent manner[1]. |
| Name | EN6 |
|---|
| Description | EN6 is a small-molecule in vivo activator of autophagy that covalently targets cysteine 277 in the ATP6V1A subunit of the lysosomal the vacuolar H+ ATPase (v-ATPase). EN6-mediated ATP6V1A modification decouples the v-ATPase from the Rags, leading to inhibition of mTORC1 signaling, increased lysosomal acidification and activation of autophagy. EN6 clears TDP-43 aggregates, a causative agent in frontotemporal dementia, in a lysosome-dependent manner[1]. |
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| References |
| Molecular Formula | C19H14F2N4O2 |
|---|---|
| Molecular Weight | 368.34 |