Bictegravir Sodium
Modify Date: 2024-01-08 21:40:32
Bictegravir Sodium structure
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Common Name | Bictegravir Sodium | ||
|---|---|---|---|---|
| CAS Number | 1807988-02-8 | Molecular Weight | 471.362 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H17F3N3NaO5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Bictegravir SodiumBictegravir sodium is a potent inhibitor of HIV-1 integrase, with an IC50 of 7.5 nM. Bictegravir sodium exhibits potent and selective anti-HIV activity and low cytotoxicity[1]. |
| Name | Bictegravir sodium |
|---|---|
| Synonym | More Synonyms |
| Description | Bictegravir sodium is a potent inhibitor of HIV-1 integrase, with an IC50 of 7.5 nM. Bictegravir sodium exhibits potent and selective anti-HIV activity and low cytotoxicity[1]. |
|---|---|
| Related Catalog | |
| Target |
HIV-1 |
| In Vitro | Bictegravir sodium potently inhibits HIV-1 replication in both MT-2 and MT-4 cells with EC50s of 1.5 and 2.4 nM, respectively, and selectivity indices (50% cytotoxic concentration [CC50]/EC50) of ∼6,800 in MT-2 cells and ∼1,500 in MT-4 cells[1]. |
| References |
| Molecular Formula | C21H17F3N3NaO5 |
|---|---|
| Molecular Weight | 471.362 |
| Exact Mass | 471.101807 |
| Storage condition | -20°C |
| GS-9883-01 |
| (2R,5S,13aR)-8-hydroxy-7,9-dioxo-N-[(2,4,6-trifluorophenyl)methyl]-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide monosodium salt |
| 4L5MP1Y7W7 |
| Bictegravir sodium |
| 2,5-Methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide, 2,3,4,5,7,9,13,13a-octahydro-8-hydroxy-7,9-dioxo-N-[(2,4,6-trifluorophenyl)methyl]-, sodium salt, (2R,5S,13aR)- (1:1) |
| GS-9883 |
| Sodium (1S,11R,13R)-3,6-dioxo-7-[(2,4,6-trifluorobenzyl)carbamoyl]-12-oxa-2,9-diazatetracyclo[11.2.1.02,11.04,9]hexadeca-4,7-dien-5-olate |
| UNII:4L5MP1Y7W7 |