JP-153
Modify Date: 2025-12-02 11:43:30
JP-153 structure
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Common Name | JP-153 | ||
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| CAS Number | 1802937-26-3 | Molecular Weight | 365.385 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H19NO5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of JP-153JP-153 (JP153) is a novel small molecule targets the Src-FAK-Paxillin signaling, inhibits Src-dependent phosphorylation of paxillin (Y118) and downstream activation of Akt (S473) in RECs; potently inhibits VEGF-induced proliferation and migration, inhibits retinal neovascularization in the murine oxygen-induced retinopathy model. |
| Name | JP-153 |
|---|
| Description | JP-153 (JP153) is a novel small molecule targets the Src-FAK-Paxillin signaling, inhibits Src-dependent phosphorylation of paxillin (Y118) and downstream activation of Akt (S473) in RECs; potently inhibits VEGF-induced proliferation and migration, inhibits retinal neovascularization in the murine oxygen-induced retinopathy model. |
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| References | References 1. Toutounchian JJ, et al. Mol Pharmacol. 2017 Jan;91(1):1-13. View Related Products by Target Src |
| Molecular Formula | C21H19NO5 |
|---|---|
| Molecular Weight | 365.385 |
| InChIKey | NIDMIFDHMDRHLS-UHFFFAOYSA-N |
| SMILES | COc1cc(C2OC(=O)Nc3c2ccc2ccccc32)cc(OC)c1OC |