ITH 12575

Modify Date: 2024-01-12 12:03:21

ITH 12575 structure	Common Name	ITH 12575
	CAS Number	1802013-08-6	Molecular Weight	331.860
	Density	1.2±0.1 g/cm3	Boiling Point	484.5±45.0 °C at 760 mmHg
	Molecular Formula	C₁₈H₁₈ClNOS	Melting Point	N/A
	MSDS	N/A	Flash Point	246.8±28.7 °C

Use of ITH 12575

ITH12575, a CGP37157 derivative, is a potent and selective mNCX blocker. ITH12575 reduces Ca2+ influx through CALHM1 at low micromolar concentrations[1][2].

Name	ITH12575
Synonym	More Synonyms

Description	ITH12575, a CGP37157 derivative, is a potent and selective mNCX blocker. ITH12575 reduces Ca2+ influx through CALHM1 at low micromolar concentrations[1][2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Neurological Disease
References	[1]. Francisco J Martínez-Sanz, et al. Benzothiazepine CGP37157 Analogues Exert Cytoprotection in Various in Vitro Models of Neurodegeneration. ACS Chem Neurosci. 2015 Sep 16;6(9):1626-36. [2]. Ana J Moreno-Ortega, et al. Benzothiazepine CGP37157 and its 2'-isopropyl analogue modulate Ca2+ entry through CALHM1. Neuropharmacology. 2015 Aug;95:503-10.

Description

ITH12575, a CGP37157 derivative, is a potent and selective mNCX blocker. ITH12575 reduces Ca2+ influx through CALHM1 at low micromolar concentrations[1][2].

Related Catalog

Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel

Research Areas >> Neurological Disease

References

[1]. Francisco J Martínez-Sanz, et al. Benzothiazepine CGP37157 Analogues Exert Cytoprotection in Various in Vitro Models of Neurodegeneration. ACS Chem Neurosci. 2015 Sep 16;6(9):1626-36.

[2]. Ana J Moreno-Ortega, et al. Benzothiazepine CGP37157 and its 2'-isopropyl analogue modulate Ca2+ entry through CALHM1. Neuropharmacology. 2015 Aug;95:503-10.

Density	1.2±0.1 g/cm3
Boiling Point	484.5±45.0 °C at 760 mmHg
Molecular Formula	C₁₈H₁₈ClNOS
Molecular Weight	331.860
Flash Point	246.8±28.7 °C
Exact Mass	331.079773
LogP	5.76
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.604

7-Chloro-5-(2'-isopropylphenyl)-3,5-dihydro-4,1-benzothiazepin-2-(1H)-one

4,1-Benzothiazepin-2(3H)-one, 7-chloro-1,5-dihydro-5-[2-(1-methylethyl)phenyl]-

7-Chloro-5-(2-isopropylphenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one

ITH12575

MFCD30720887

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: ITH 12575
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: ITH12575
Price: $500.0/100mg $800.0/250mg $1600.0/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Get all suppliers and price by the below link:

ITH 12575 suppliers

ITH 12575 price

ITH 12575

Use of ITH 12575

Names

ITH 12575 Biological Activity

Chemical & Physical Properties

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.