THIQ40
Modify Date: 2024-02-25 17:49:48
THIQ40 structure
|
Common Name | THIQ40 | ||
|---|---|---|---|---|
| CAS Number | 1799430-91-3 | Molecular Weight | 427.544 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C28H29NO3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of THIQ40THIQ 40 (THIQ40) is a potent, orally available ERα antagonist and selective estrogen receptor degrader (SERD) with IC50 of 17 nM (ERα binding) and 30 nM (ERα transcription), IC50 of 0.9 nM (ERα degradation); potently inhibits insulin driven proliferation in MCF-7 cells with IC50 of 2.1 nM, downregulate ERα protein levels and inhibit MCF-7 proliferation in an estradiol-independent manner; demonstrated SERD activity at tolerated and efficacious exposures in vivo. |
| Name | THIQ 40 |
|---|
| Description | THIQ 40 (THIQ40) is a potent, orally available ERα antagonist and selective estrogen receptor degrader (SERD) with IC50 of 17 nM (ERα binding) and 30 nM (ERα transcription), IC50 of 0.9 nM (ERα degradation); potently inhibits insulin driven proliferation in MCF-7 cells with IC50 of 2.1 nM, downregulate ERα protein levels and inhibit MCF-7 proliferation in an estradiol-independent manner; demonstrated SERD activity at tolerated and efficacious exposures in vivo. |
|---|---|
| References | References 1. Burks HE, et al. J Med Chem. 2017 Apr 13;60(7):2790-2818. View Related Products by Target Estrogen Receptor/ERR |
| Molecular Formula | C28H29NO3 |
|---|---|
| Molecular Weight | 427.544 |