Exicorilant
Modify Date: 2024-01-16 17:39:07
Exicorilant structure
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Common Name | Exicorilant | ||
|---|---|---|---|---|
| CAS Number | 1781244-77-6 | Molecular Weight | 589.56 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C26H23F4N7O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ExicorilantExicorilant (CORT 125281) is a selective and oral active glucocorticoid receptor (GR) antagonist, with a Ki value of 7 nM[1]. Exicorilant (CORT 125281) has potential to overcome adiposity, glucose intolerance and dyslipidaemia[2]. |
| Name | Exicorilant |
|---|
| Description | Exicorilant (CORT 125281) is a selective and oral active glucocorticoid receptor (GR) antagonist, with a Ki value of 7 nM[1]. Exicorilant (CORT 125281) has potential to overcome adiposity, glucose intolerance and dyslipidaemia[2]. |
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| Related Catalog | |
| Target |
Ki: 7 nM (GR)[1]. |
| In Vitro | Exicorilant (CORT 125281) reverses corticosterone-mediated GR activity in murine brown adipocytes in vitro[1]. |
| In Vivo | Exicorilant (CORT 125281) reduces body weight, fat mass and plasma lipids in HFD-fed mice[2]. Exicorilant (CORT 125281) (6, 20 or 60 mg/kg/d, for 3 weeks in mice) at different dosages reduce body weight, fat mass, plasma TG, cholesterol and FFA in a dose-dependent manner, with no effect on lean mass[2]. Animal Model: Ten-week old male C57BL/6J mice HFD-fed[2]. Dosage: 6, 20, 60 mg/kg. Administration: Orally mixed with food daily for 3 weeks. Result: Reduced HFD-induced body weight gain with approximately 10% for CORT125281 at d21. Significantly lowered plasma TG (-56%) and cholesterol levels (-30%). |
| References |
| Molecular Formula | C26H23F4N7O3S |
|---|---|
| Molecular Weight | 589.56 |
| InChIKey | HWJYJKAURRIWJM-GKVSMKOHSA-N |
| SMILES | Cn1ncc(S(=O)(=O)N2CCC3Cc4c(cnn4-c4ccc(F)cc4)CC3(C(=O)c3cc(C(F)(F)F)ccn3)C2)n1 |