CAM741
Modify Date: 2024-09-16 08:20:14
CAM741 structure
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Common Name | CAM741 | ||
|---|---|---|---|---|
| CAS Number | 177586-74-2 | Molecular Weight | 1038.36 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C56H91N7O11 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CAM741CAM741 is a selective VCAM-1 translocation inhibitor. CAM741 selectively inhibits VCAM-1 expression by inhibiting its co-translational translocation within the lumen of the endoplasmic reticulum (ER). CAM741 can be used as a molecular tool and can also be used in the research of chronic inflammation and cancer[1][2]. |
| Name | CAM741 |
|---|
| Description | CAM741 is a selective VCAM-1 translocation inhibitor. CAM741 selectively inhibits VCAM-1 expression by inhibiting its co-translational translocation within the lumen of the endoplasmic reticulum (ER). CAM741 can be used as a molecular tool and can also be used in the research of chronic inflammation and cancer[1][2]. |
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| Related Catalog | |
| In Vitro | CAM741 (5, 10, 50, 100 nM; 24 h) 剂量依赖性地抑制瞬时转染的 HEK-293 细胞中 VCAM1 糖蛋白的表达[1]。 CAM741 (10, 33, 100, 333 nM; 24 h) 剂量依赖地抑制 VCAM1 的共翻译易位[1]。 CAM741在后靶向步骤抑制 VCAM1 易位，并增强 VCAM1 新生链与 Sec61 β 的相互作用[1]。 Western Blot Analysis[1] Cell Line: HEK-293 cells Concentration: 5, 10, 50, 100 nM Incubation Time: 24 h Result: Inhibited VCAM1 glycoprotein expression in a dose-dependent manner. |
| References |
| Molecular Formula | C56H91N7O11 |
|---|---|
| Molecular Weight | 1038.36 |
| InChIKey | VDFZHYIUDDBVPN-IVUNSTSTSA-N |
| SMILES | CCCCC(C)CC1NC(=O)C(Cc2cn(OC)c3ccccc23)N(C)C(=O)C(CC(C)C)NC(=O)C(CC(C)C)N(C)C(=O)C(CC(C)CCCC)NC(=O)C(CCC(=O)OCCC)OC(=O)C(C)N(C)C1=O |