CAM741

Names

[ Name ]:
CAM741

Biological Activity

[Description]:

CAM741 is a selective VCAM-1 translocation inhibitor. CAM741 selectively inhibits VCAM-1 expression by inhibiting its co-translational translocation within the lumen of the endoplasmic reticulum (ER). CAM741 can be used as a molecular tool and can also be used in the research of chronic inflammation and cancer[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[In Vitro]

CAM741 (5, 10, 50, 100 nM; 24 h) 剂量依赖性地抑制瞬时转染的 HEK-293 细胞中 VCAM1 糖蛋白的表达[1]。 CAM741 (10, 33, 100, 333 nM; 24 h) 剂量依赖地抑制 VCAM1 的共翻译易位[1]。 CAM741在后靶向步骤抑制 VCAM1 易位，并增强 VCAM1 新生链与 Sec61 β 的相互作用[1]。 Western Blot Analysis[1] Cell Line: HEK-293 cells Concentration: 5, 10, 50, 100 nM Incubation Time: 24 h Result: Inhibited VCAM1 glycoprotein expression in a dose-dependent manner.

[References]

[1]. Besemer J, et al. Selective inhibition of cotranslational translocation of vascular cell adhesion molecule 1. Nature. 2005 Jul 14;436(7048):290-3.

[2]. Eva Pauwels, et al. Inhibitors of the Sec61 Complex and Novel High Throughput Screening Strategies to T arget the Protein T ranslocation Pathway. Int J Mol Sci 2021, 22(21), 12007.

Chemical & Physical Properties

[ Molecular Formula ]:
C₅₆H₉₁N₇O₁₁

[ Molecular Weight ]:
1038.36

Related Compounds

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