2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid

Modify Date: 2025-08-25 09:18:01

2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid structure	Common Name	2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid
	CAS Number	176983-21-4	Molecular Weight	486.683
	Density	1.2±0.1 g/cm3	Boiling Point	616.9±55.0 °C at 760 mmHg
	Molecular Formula	C₃₀H₄₆O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	340.9±28.0 °C

Use of 2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid

2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid, a natural ursane-type triterpene, is a potent inhibitor of HIV Protease (HIV Protease). 2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid is also an inhibitor of the activation of Epstein-Barr virus early antigen (EBV-EA). 2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid displays an inhibitory activity against nitric oxide production in Lipopolysaccharide (Lipopolysaccharides)-activated RAW 264.7 cells[1][2].

Name	(2α)-2,19-Dihydroxy-3-oxours-12-en-28-oic acid
Synonym	More Synonyms

Description	2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid, a natural ursane-type triterpene, is a potent inhibitor of HIV Protease (HIV Protease). 2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid is also an inhibitor of the activation of Epstein-Barr virus early antigen (EBV-EA). 2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid displays an inhibitory activity against nitric oxide production in Lipopolysaccharide (Lipopolysaccharides)-activated RAW 264.7 cells[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Anti-infection >> HSV Research Areas >> Infection Signaling Pathways >> Metabolic Enzyme/Protease >> HIV Protease
In Vitro	2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid (0.01-0.1 μM) 在脂多糖激活的巨噬细胞系、RAW 264.7 细胞中显示出对一氧化氮产生的中等抑制活性[1 ]。
In Vivo	2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid (0.0025%；饮用水；20 周) 显示出对 TPA 诱导的 EBV-EA 激活的抑制作用，并导致显着延迟小鼠皮肤两阶段癌变[2]。 Animal Model: Female ICR mice (6 weeks old)[2] Dosage: 0.0025% Administration: Drinking water; for 20 weeks Result: Showed an inhibitory effect on the activation of EBV-EA induced by 12-O-tetradecanoylphorbol-13-acetate (TPA).
References	[1]. Xiao-Peng Wu, et al. A new ursane-type triterpene, cymosic acid from Rosa cymosa. J Asian Nat Prod Res. 2014;16(4):422-5. [2]. Shoko Taniguchi, et al. Production of bioactive triterpenes by Eriobotrya japonica calli. Phytochemistry. 2002 Feb;59(3):315-23.

Density	1.2±0.1 g/cm3
Boiling Point	616.9±55.0 °C at 760 mmHg
Molecular Formula	C₃₀H₄₆O₅
Molecular Weight	486.683
Flash Point	340.9±28.0 °C
Exact Mass	486.334534
LogP	5.45
Vapour Pressure	0.0±4.0 mmHg at 25°C
Index of Refraction	1.574
InChIKey	LJORXTIGOHMBOS-CMDFFPTJSA-N
SMILES	CC1CCC2(C(=O)O)CCC3(C)C(=CCC4C5(C)CC(O)C(=O)C(C)(C)C5CCC43C)C2C1(C)O
Storage condition	2-8℃

2α,19α-dihydroxy-3-oxo-12-ursen-28-oic acid

(2α)-2,19-Dihydroxy-3-oxours-12-en-28-oic acid

Urs-12-en-28-oic acid, 2,19-dihydroxy-3-oxo-, (2α)-

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid

Use of 2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid

Names

Biological Activity

Chemical & Physical Properties

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.