Swertiamarin

Modify Date: 2024-01-02 10:33:36

Swertiamarin Structure
Swertiamarin structure
Common Name Swertiamarin
CAS Number 17388-39-5 Molecular Weight 374.340
Density 1.6±0.1 g/cm3 Boiling Point 649.3±55.0 °C at 760 mmHg
Molecular Formula C16H22O10 Melting Point 111ºC
MSDS Chinese USA Flash Point 237.7±25.0 °C

 Use of Swertiamarin


Swertiamarin, a secoiridoid glycoside found in genera of Enicostemma Species, confers anti-hyperglycemic and anti-hyperlipidemic effects[1].

 Names

Name Swertiamarine
Synonym More Synonyms

 Swertiamarin Biological Activity

Description Swertiamarin, a secoiridoid glycoside found in genera of Enicostemma Species, confers anti-hyperglycemic and anti-hyperlipidemic effects[1].
Related Catalog
References

[1]. Patel N, et al. Curr Drug Targets. 2018;19(16):1958-1967. doi: 10.2174/1389450119666180406113428.

 Chemical & Physical Properties

Density 1.6±0.1 g/cm3
Boiling Point 649.3±55.0 °C at 760 mmHg
Melting Point 111ºC
Molecular Formula C16H22O10
Molecular Weight 374.340
Flash Point 237.7±25.0 °C
Exact Mass 374.121307
PSA 155.14000
LogP -3.15
Vapour Pressure 0.0±4.4 mmHg at 25°C
Index of Refraction 1.626
Storage condition ?20°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UQ1366700
CHEMICAL NAME :
1H,3H-Pyrano(3,4-c)pyran-1-one, 4,4a,5,6-tetrahydro-5-ethenyl-6-(beta-d-glucopyranosy loxy)-4a-hydroxy-, (4aR-(4a-alpha,5-beta,6-alpha))-
CAS REGISTRY NUMBER :
17388-39-5
BEILSTEIN REFERENCE NO. :
0055278
LAST UPDATED :
199806
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C16-H22-O10
MOLECULAR WEIGHT :
374.38

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity)
REFERENCE :
CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 13,464,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>8 gm/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity)
REFERENCE :
CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 13,464,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity)
REFERENCE :
CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 13,464,1982

 Safety Information

Hazard Codes C
Risk Phrases R23:Toxic by inhalation. R34:Causes burns.
Safety Phrases S26-S36-S45
RIDADR UN 1789
WGK Germany 3.0
RTECS UQ1366700
Packaging Group III
Hazard Class 8

 Articles29

More Articles
Development and validation of a LC-ESI-MS/MS method for the determination of swertiamarin in rat plasma and its application in pharmacokinetics.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 879(19) , 1653-8, (2011)

A new LC-ESI-MS/MS assay method has been developed and validated for the quantification of swertiamarin, a representative bioactive substance of Swertia plants, in rat plasma using gentiopicroside, an...

Hypoglycemic activity of C-glycosyl flavonoid from Enicostemma hyssopifolium.

Pharm. Biol. 49(4) , 383-91, (2011)

Enicostemma hyssopifolium Verdoon (Gentianaceae) has been documented for various therapeutic effects in traditional systems of medicine; the hypoglycemic and hypolipidemic activities are also well rep...

Antihyperlipidaemic activity of swertiamarin, a secoiridoid glycoside in poloxamer-407-induced hyperlipidaemic rats.

J. Nat. Med. 63(4) , 437-42, (2009)

We have investigated antihyperlipidaemic effect of swertiamarin (50 mg/kg, oral once) isolated from the perennial herb Enicostemma littorale Blume in poloxamer 407 (P-407)-induced hyperlipidaemic rats...

 Synonyms

MFCD07783984
(4aR,5R,6S)-5-ethenyl-4a-hydroxy-1-oxo-4,4a,5,6-tetrahydro-1H,3H-pyrano[3,4-c]pyran-6-yl β-D-glucopyranoside
1H,3H-Pyrano[3,4-c]pyran-1-one, 5-ethenyl-6-(β-D-glucopyranosyloxy)-4,4a,5,6-tetrahydro-4a-hydroxy-, (4aR,5R,6S)-
(4aR,5R,6S)-4a-Hydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-5-vinyl-4,4a,5,6-tetrahydro-1H,3H-pyrano[3,4-c]pyran-1-one
(4aR,5R,6S)-5-Ethenyl-4a-hydroxy-1-oxo-4,4a,5,6-tetrahydro-1H,3H-pyrano[3,4-c]pyr-6-yl-β-D-glucopyranoside
4,4a,5,6-Tetrahydro-4aa-hydroxy-1-oxo-5b-vinyl-1H,3H-pyrano[3,4-c]pyran-6-yl b-D-Glucopyranoside
(4aR,5R,6S)-4a-Hydroxy-1-oxo-5-vinyl-4,4a,5,6-tetrahydro-1H,3H-pyrano[3,4-c]pyran-6-yl β-D-glucopyranoside
1H,3H-Pyrano(3,4-c)pyran-1-one, 5-ethenyl-6-(β-d-glucopyranosyloxy)-4,4a,5,6-tetrahydro-4a-hydroxy-, (4aR,5R,6S)-
Swertiamarin
[4aR-(4aa,5b,6a)]-5-Ethenyl-6-(b-D-glucopyranosyloxy)-4,4a,5,6-tetrahydro-4a-hydroxy-1H,3H-pyrano[3,4-c]pyran-1-one
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