Swertiamarin structure
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Common Name | Swertiamarin | ||
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CAS Number | 17388-39-5 | Molecular Weight | 374.340 | |
Density | 1.6±0.1 g/cm3 | Boiling Point | 649.3±55.0 °C at 760 mmHg | |
Molecular Formula | C16H22O10 | Melting Point | 111ºC | |
MSDS | Chinese USA | Flash Point | 237.7±25.0 °C |
Use of SwertiamarinSwertiamarin, a secoiridoid glycoside found in genera of Enicostemma Species, confers anti-hyperglycemic and anti-hyperlipidemic effects[1]. |
Name | Swertiamarine |
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Synonym | More Synonyms |
Description | Swertiamarin, a secoiridoid glycoside found in genera of Enicostemma Species, confers anti-hyperglycemic and anti-hyperlipidemic effects[1]. |
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Related Catalog | |
References |
[1]. Patel N, et al. Curr Drug Targets. 2018;19(16):1958-1967. doi: 10.2174/1389450119666180406113428. |
Density | 1.6±0.1 g/cm3 |
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Boiling Point | 649.3±55.0 °C at 760 mmHg |
Melting Point | 111ºC |
Molecular Formula | C16H22O10 |
Molecular Weight | 374.340 |
Flash Point | 237.7±25.0 °C |
Exact Mass | 374.121307 |
PSA | 155.14000 |
LogP | -3.15 |
Vapour Pressure | 0.0±4.4 mmHg at 25°C |
Index of Refraction | 1.626 |
Storage condition | ?20°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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Hazard Codes | C |
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Risk Phrases | R23:Toxic by inhalation. R34:Causes burns. |
Safety Phrases | S26-S36-S45 |
RIDADR | UN 1789 |
WGK Germany | 3.0 |
RTECS | UQ1366700 |
Packaging Group | III |
Hazard Class | 8 |
Development and validation of a LC-ESI-MS/MS method for the determination of swertiamarin in rat plasma and its application in pharmacokinetics.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 879(19) , 1653-8, (2011) A new LC-ESI-MS/MS assay method has been developed and validated for the quantification of swertiamarin, a representative bioactive substance of Swertia plants, in rat plasma using gentiopicroside, an... |
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Hypoglycemic activity of C-glycosyl flavonoid from Enicostemma hyssopifolium.
Pharm. Biol. 49(4) , 383-91, (2011) Enicostemma hyssopifolium Verdoon (Gentianaceae) has been documented for various therapeutic effects in traditional systems of medicine; the hypoglycemic and hypolipidemic activities are also well rep... |
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Antihyperlipidaemic activity of swertiamarin, a secoiridoid glycoside in poloxamer-407-induced hyperlipidaemic rats.
J. Nat. Med. 63(4) , 437-42, (2009) We have investigated antihyperlipidaemic effect of swertiamarin (50 mg/kg, oral once) isolated from the perennial herb Enicostemma littorale Blume in poloxamer 407 (P-407)-induced hyperlipidaemic rats... |
MFCD07783984 |
(4aR,5R,6S)-5-ethenyl-4a-hydroxy-1-oxo-4,4a,5,6-tetrahydro-1H,3H-pyrano[3,4-c]pyran-6-yl β-D-glucopyranoside |
1H,3H-Pyrano[3,4-c]pyran-1-one, 5-ethenyl-6-(β-D-glucopyranosyloxy)-4,4a,5,6-tetrahydro-4a-hydroxy-, (4aR,5R,6S)- |
(4aR,5R,6S)-4a-Hydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-5-vinyl-4,4a,5,6-tetrahydro-1H,3H-pyrano[3,4-c]pyran-1-one |
(4aR,5R,6S)-5-Ethenyl-4a-hydroxy-1-oxo-4,4a,5,6-tetrahydro-1H,3H-pyrano[3,4-c]pyr-6-yl-β-D-glucopyranoside |
4,4a,5,6-Tetrahydro-4aa-hydroxy-1-oxo-5b-vinyl-1H,3H-pyrano[3,4-c]pyran-6-yl b-D-Glucopyranoside |
(4aR,5R,6S)-4a-Hydroxy-1-oxo-5-vinyl-4,4a,5,6-tetrahydro-1H,3H-pyrano[3,4-c]pyran-6-yl β-D-glucopyranoside |
1H,3H-Pyrano(3,4-c)pyran-1-one, 5-ethenyl-6-(β-d-glucopyranosyloxy)-4,4a,5,6-tetrahydro-4a-hydroxy-, (4aR,5R,6S)- |
Swertiamarin |
[4aR-(4aa,5b,6a)]-5-Ethenyl-6-(b-D-glucopyranosyloxy)-4,4a,5,6-tetrahydro-4a-hydroxy-1H,3H-pyrano[3,4-c]pyran-1-one |