Norbiotinamine

Modify Date: 2025-08-26 19:12:19

Norbiotinamine Structure
Norbiotinamine structure
Common Name Norbiotinamine
CAS Number 173401-47-3 Molecular Weight 215.32
Density N/A Boiling Point N/A
Molecular Formula C9H17N3OS Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Norbiotinamine


Norbiotinamine is an alternative to biotin. Norbiotinamine can be coupled with a carboxylic group of amino acids to give inverse peptides, having the amide linkage oriented in the opposite direction[1].

 Names

Name Norbiotinamine

 Norbiotinamine Biological Activity

Description Norbiotinamine is an alternative to biotin. Norbiotinamine can be coupled with a carboxylic group of amino acids to give inverse peptides, having the amide linkage oriented in the opposite direction[1].
Related Catalog
In Vitro In order to couple biotin to amino acids, reaction has to be with an amino group. An example is biocytin (biotin lysine). However, Norbiotinamine could be coupled with a carboxylic group of amino acids to give inverse peptides, having the amide linkage oriented in the opposite direction. As an example, Norbiotinamine is coupled with the NHS ester of N-Boc-glutamic acid γ-benzyl ester. The resulting norbiotinylamide of γglutamic acid (VII), obtained after deprotection, is similar to biocytin, but it has a shorter aliphatic chain and an inverted amide bond[1].
References

[1]. Szalecki W.Synthesis of Norbiotinamine and its derivatives. Bioconjug Chem. 1996 Mar-Apr;7(2):271-3.

[2]. Zhou GC, et al. Design, synthesis and evaluation of a cellular stable and detectable biotinylated fumagillin probe and investigation of cell permeability of fumagillin and its analogs to endothelial and cancer cells.Eur J Med Chem. 2013;70:631-9.

 Chemical & Physical Properties

Molecular Formula C9H17N3OS
Molecular Weight 215.32
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