160385-86-4
160385-86-4 structure
- Name: Norbiotinamine hydrochloride
- Chemical Name: Norbiotinamine hydrochloride
- CAS Number: 160385-86-4
- Molecular Formula: C9H18ClN3OS
- Molecular Weight: 251.78
- Catalog: Research Areas Cancer
- Create Date: 2020-04-21 17:06:52
- Modify Date: 2025-08-26 22:17:34
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Norbiotinamine hydrochloride is an alternative to biotin. Norbiotinamine can be coupled with a carboxylic group of amino acids to give inverse peptides, having the amide linkage oriented in the opposite direction[1].
| Name | Norbiotinamine hydrochloride |
|---|
| Description | Norbiotinamine hydrochloride is an alternative to biotin. Norbiotinamine can be coupled with a carboxylic group of amino acids to give inverse peptides, having the amide linkage oriented in the opposite direction[1]. |
|---|---|
| Related Catalog | |
| In Vitro | In order to couple biotin to amino acids, reaction has to be with an amino group. An example is biocytin (biotin lysine). However, Norbiotinamine could be coupled with a carboxylic group of amino acids to give inverse peptides, having the amide linkage oriented in the opposite direction. As an example, Norbiotinamine is coupled with the NHS ester of N-Boc-glutamic acid γ-benzyl ester. The resulting norbiotinylamide of γglutamic acid (VII), obtained after deprotection, is similar to biocytin, but it has a shorter aliphatic chain and an inverted amide bond[1]. |
| References |
[1]. Szalecki W.Synthesis of Norbiotinamine and its derivatives. Bioconjug Chem. 1996 Mar-Apr;7(2):271-3. |
| Molecular Formula | C9H18ClN3OS |
|---|---|
| Molecular Weight | 251.78 |