Isocucurbitacin B

Modify Date: 2024-01-03 15:40:24

Isocucurbitacin B Structure
Isocucurbitacin B structure
Common Name Isocucurbitacin B
CAS Number 17278-28-3 Molecular Weight 558.703
Density 1.2±0.1 g/cm3 Boiling Point 702.4±60.0 °C at 760 mmHg
Molecular Formula C32H46O8 Melting Point N/A
MSDS N/A Flash Point 219.9±26.4 °C

 Use of Isocucurbitacin B


Isocucurbitacin B is a potent cytotoxic compound isolated from Helicteres rswa L. (Sterculiaceae). Isocucurbitacin B possesses anti-tumor acticity[1][2].

 Names

Name [(E,6R)-6-[(3S,8S,9R,10R,13R,14S,16R,17R)-3,16-dihydroxy-4,4,9,13,14-pentamethyl-2,11-dioxo-3,7,8,10,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-hydroxy-2-methyl-5-oxohept-3-en-2-yl] acetate
Synonym More Synonyms

 Isocucurbitacin B Biological Activity

Description Isocucurbitacin B is a potent cytotoxic compound isolated from Helicteres rswa L. (Sterculiaceae). Isocucurbitacin B possesses anti-tumor acticity[1][2].
Related Catalog
References

[1]. MF Bean, et al. Cucurbitacin B and isocucurbitacin B: cytotoxic components of Helicteres isora. Journal of Natural Products. 1985.

[2]. SM Kupchan, et al. Tumor Inhibitors. XXIII.1 The Cytotoxic Principles of Marah oreganus.H. Cytotoxic principles of Marah oreganus H. 1976.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 702.4±60.0 °C at 760 mmHg
Molecular Formula C32H46O8
Molecular Weight 558.703
Flash Point 219.9±26.4 °C
Exact Mass 558.319275
PSA 138.20000
LogP 2.06
Vapour Pressure 0.0±5.0 mmHg at 25°C
Index of Refraction 1.568

 Synonyms

(1S,4R,9β,16α,23E)-1,16,20-Trihydroxy-9,10,14-trimethyl-2,11,22-trioxo-4,9-cyclo-9,10-secocholesta-5,23-dien-25-yl acetate
Isocucurbitacin B
2-EPICUCURBITICIN B
CUCURBITCIN B,2-EPI
Estr-5-ene-2,11-dione, 17-[(1R,3E)-5-(acetyloxy)-1-hydroxy-1,5-dimethyl-2-oxo-3-hexen-1-yl]-3,16-dihydroxy-4,4,9,14-tetramethyl-, (3α,9β,10α,16α,17β)-
19-Norlanosta-5,23-diene-2,11,22-trione, 25-(acetyloxy)-3,16,20-trihydroxy-9-methyl-, (3α,9β,10α,16α,23E)-