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Isocucurbitacin B

Names

[ CAS No. ]:
17278-28-3

[ Name ]:
Isocucurbitacin B

[Synonym ]:
(1S,4R,9β,16α,23E)-1,16,20-Trihydroxy-9,10,14-trimethyl-2,11,22-trioxo-4,9-cyclo-9,10-secocholesta-5,23-dien-25-yl acetate
Isocucurbitacin B
2-EPICUCURBITICIN B
CUCURBITCIN B,2-EPI
Estr-5-ene-2,11-dione, 17-[(1R,3E)-5-(acetyloxy)-1-hydroxy-1,5-dimethyl-2-oxo-3-hexen-1-yl]-3,16-dihydroxy-4,4,9,14-tetramethyl-, (3α,9β,10α,16α,17β)-
19-Norlanosta-5,23-diene-2,11,22-trione, 25-(acetyloxy)-3,16,20-trihydroxy-9-methyl-, (3α,9β,10α,16α,23E)-

Biological Activity

[Description]:

Isocucurbitacin B is a potent cytotoxic compound isolated from Helicteres rswa L. (Sterculiaceae). Isocucurbitacin B possesses anti-tumor acticity[1][2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[References]

[1]. MF Bean, et al. Cucurbitacin B and isocucurbitacin B: cytotoxic components of Helicteres isora. Journal of Natural Products. 1985.

[2]. SM Kupchan, et al. Tumor Inhibitors. XXIII.1 The Cytotoxic Principles of Marah oreganus.H. Cytotoxic principles of Marah oreganus H. 1976.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
702.4±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C32H46O8

[ Molecular Weight ]:
558.703

[ Flash Point ]:
219.9±26.4 °C

[ Exact Mass ]:
558.319275

[ PSA ]:
138.20000

[ LogP ]:
2.06

[ Vapour Pressure ]:
0.0±5.0 mmHg at 25°C

[ Index of Refraction ]:
1.568

Related Compounds