Nepicastat (hydrochloride) structure
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Common Name | Nepicastat (hydrochloride) | ||
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CAS Number | 170151-24-3 | Molecular Weight | 331.812 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C14H16ClF2N3S | Melting Point | N/A | |
MSDS | Chinese USA | Flash Point | N/A | |
Symbol |
GHS07 |
Signal Word | Warning |
Use of Nepicastat (hydrochloride)Nepicastat Hcl(SYN117 Hcl; RS-25560-197 Hcl) is a dopamine beta-hydroxylase inhibitor with IC50 of 8.5 ± 0.8 and 9.0 ± 0.8 nM for bovine and human, respectively. IC50 value: 8.5/9.0 nM(bovine/human dopamine beta-hydroxylase)Dopamine beta-hydroxylase is an enzyme that catalyzes the conversion of dopamine to norepinephrine. Nepicastat (SYN117; RS-25560-197) has been studied as a possible treatment for congestive heart failure, and appears to be well tolerated as such. |
Name | 4-(aminomethyl)-3-[(2S)-5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl]-1H-imidazole-2-thione,hydrochloride |
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Synonym | More Synonyms |
Description | Nepicastat Hcl(SYN117 Hcl; RS-25560-197 Hcl) is a dopamine beta-hydroxylase inhibitor with IC50 of 8.5 ± 0.8 and 9.0 ± 0.8 nM for bovine and human, respectively. IC50 value: 8.5/9.0 nM(bovine/human dopamine beta-hydroxylase)Dopamine beta-hydroxylase is an enzyme that catalyzes the conversion of dopamine to norepinephrine. Nepicastat (SYN117; RS-25560-197) has been studied as a possible treatment for congestive heart failure, and appears to be well tolerated as such. |
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Related Catalog | |
References |
Molecular Formula | C14H16ClF2N3S |
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Molecular Weight | 331.812 |
Exact Mass | 331.072144 |
PSA | 78.83000 |
LogP | 4.51490 |
Appearance of Characters | white to beige |
Storage condition | ?20°C |
Water Solubility | DMSO: soluble10mg/mL, clear |
Symbol |
GHS07 |
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Signal Word | Warning |
Hazard Statements | H315-H319-H335 |
Precautionary Statements | P261-P305 + P351 + P338 |
Hazard Codes | Xi |
Risk Phrases | 36/37/38 |
Safety Phrases | 26 |
RIDADR | NONH for all modes of transport |
Nepicastat HCl |
SYN117 |
Nepitat HCl |
Nepicastat hydrochloride |
UNII-3WK068D17I |
5-(Aminomethyl)-1-[(2S)-5,7-difluoro-1,2,3,4-tetrahydro-2-naphthalenyl]-1,3-dihydro-2H-imidazole-2-thione hydrochloride (1:1) |
2H-Imidazole-2-thione, 5-(aminomethyl)-1-[(2S)-5,7-difluoro-1,2,3,4-tetrahydro-2-naphthalenyl]-1,3-dihydro-, hydrochloride (1:1) |
Nepitat hydrochloride |
Nepicastat (hydrochloride) |