Yp537

Modify Date: 2024-01-14 09:26:54

Yp537 Structure
Yp537 structure
Common Name Yp537
CAS Number 166664-90-0 Molecular Weight N/A
Density N/A Boiling Point N/A
Molecular Formula C64H104N13O22PS Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Yp537


Yp537 is an estrogen receptor (ER) inhibitor that blocks dimerization of the human estrogen receptor[1].

 Names

Name cys-asn-val-val-pro-leu-tyr(po3h2)-asp-&

 Yp537 Biological Activity

Description Yp537 is an estrogen receptor (ER) inhibitor that blocks dimerization of the human estrogen receptor[1].
Related Catalog
In Vitro Yp537 (5-50 μM; 1 h) abolishes the formation of the hER-ERE complex. And dose not inhibit the formation of the STAT1-serum-induced element complex[1]. Yp537 binds to a SH2-like domain, and interferes with the SH2-like phosphopeptide coupling mechanism between hER monomers[1].
References

[1]. Arnold SF, et al. An antiestrogen: a phosphotyrosyl peptide that blocks dimerization of the human estrogen receptor. Proc Natl Acad Sci U S A. 1995 Aug 1;92(16):7475-9.  

 Chemical & Physical Properties

Molecular Formula C64H104N13O22PS
Appearance of Characters Solid | White to off-white
Storage condition −20°C
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