Yp537

Names

[ CAS No. ]:
166664-90-0

[ Name ]:
Yp537

Biological Activity

[Description]:

Yp537 is an estrogen receptor (ER) inhibitor that blocks dimerization of the human estrogen receptor[1].

[Related Catalog]:

Signaling Pathways >> Others >> Estrogen Receptor/ERR

Research Areas >> Endocrinology

[In Vitro]

Yp537 (5-50 μM; 1 h) abolishes the formation of the hER-ERE complex. And dose not inhibit the formation of the STAT1-serum-induced element complex[1]. Yp537 binds to a SH2-like domain, and interferes with the SH2-like phosphopeptide coupling mechanism between hER monomers[1].

[References]

[1]. Arnold SF, et al. An antiestrogen: a phosphotyrosyl peptide that blocks dimerization of the human estrogen receptor. Proc Natl Acad Sci U S A. 1995 Aug 1;92(16):7475-9.

Chemical & Physical Properties

[ Molecular Formula ]:
C₆₄H₁₀₄N₁₃O₂₂PS

[ Appearance of Characters ]:
Solid | White to off-white

[ Storage condition ]:
−20°C