GS-9901
Modify Date: 2025-08-27 20:13:48
GS-9901 structure
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Common Name | GS-9901 | ||
|---|---|---|---|---|
| CAS Number | 1640247-87-5 | Molecular Weight | 477.88 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H17ClFN9O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of GS-9901GS-9901 is a highly selective and orally active PI3Kδ inhibitor, with an IC50 of 1 nM. Has potential to treat rheumatoid arthritis[1]. |
| Name | GS-9901 |
|---|
| Description | GS-9901 is a highly selective and orally active PI3Kδ inhibitor, with an IC50 of 1 nM. Has potential to treat rheumatoid arthritis[1]. |
|---|---|
| Related Catalog | |
| Target |
PI3Kδ:1 nM (IC50) |
| In Vivo | GS-9901 (0.3/1/3 mg/kg, orally, twice daily for 7 days) demonstrates efficacy in a rat model of arthritis and is predicted to be suitable for q.d. dosing in humans[1]. Animal Model: Female Lewis rats with established collagen-induced arthritis (CIA)[1]. Dosage: 0.3 mg/kg, 1 mg/kg, and 3 mg/kg. Administration: Orally, twice-daily for 7 days starting on the 10th day after the second collagen immunization. Result: Demonstrated significant reduction in ankle swelling in rats treated with 0.3 mg/kg 35 (31% reduction), 1 mg/kg 35 (67%), and 3 mg/kg 35 (65%). Plasma concentrations measured on day 7 (12 h after last dose) were consistent with maintaining approximately 60%, 80%, and >90% inhibition of PI3Kδ at 0.3, 1.0, and 3 mg/kg doses, respectively, at trough levels. |
| References |
| Molecular Formula | C22H17ClFN9O |
|---|---|
| Molecular Weight | 477.88 |
| InChIKey | XDSXYMOZKDUASY-INIZCTEOSA-N |
| SMILES | N#Cc1c(N)nc(N)nc1NC(c1nc2c(F)ccc(Cl)c2c(=O)n1-c1cccnc1)C1CC1 |