Givosiran
Modify Date: 2025-08-27 18:00:19
Givosiran structure
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Common Name | Givosiran | ||
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| CAS Number | 1639325-43-1 | Molecular Weight | 1710.994 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 1780.6±65.0 °C at 760 mmHg | |
| Molecular Formula | C78H139N11O30 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 1030.6±34.3 °C | |
Use of GivosiranGivosiran (ALN-AS1) is a small interfering RNA that targets hepatic aminolevulinate synthase 1 (ALAS1) messenger RNA. Givosiran downregulates ALAS1 mRNA and prevents accumulation of neurotoxic δ-aminolevulinic acid and porphobilinogen levels. Givosiran can be used for the research of acute intermittent porphyria[1][2]. |
| Name | 21-[(2-Acetamido-2-deoxy-β-D-galactopyranosyl)oxy]-N-[3-({5-[(2-acetamido-2-deoxy-β-D-galactopyranosyl)oxy]pentanoyl}amino)propyl]-6-[(3-{[3-({5-[(2-acetamido-2-deoxy-β-D-galactopyranosyl)oxy]pentanoyl}amino)propyl]amino}-3-oxopropoxy)methyl]-6-({12-[(2R,4R)-4-hydroxy-2-methyl-1-pyrrolidinyl]-12-oxododecanoyl}amino)-11,17-dioxo-4,8-dioxa-12,16-diazahenicosan-1-amide |
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| Synonym | More Synonyms |
| Description | Givosiran (ALN-AS1) is a small interfering RNA that targets hepatic aminolevulinate synthase 1 (ALAS1) messenger RNA. Givosiran downregulates ALAS1 mRNA and prevents accumulation of neurotoxic δ-aminolevulinic acid and porphobilinogen levels. Givosiran can be used for the research of acute intermittent porphyria[1][2]. |
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| Related Catalog | |
| In Vitro | Givosiran is conjugated to a trivalent N-acetylgalactosamine ligand, which binds specifically to the asialoglycoprotein receptor, enabling targeted delivery to hepatocytes[2]. |
| References |
[1]. Scott LJ. Givosiran: First Approval. Drugs. 2020 Feb;80(3):335-339. |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 1780.6±65.0 °C at 760 mmHg |
| Molecular Formula | C78H139N11O30 |
| Molecular Weight | 1710.994 |
| Flash Point | 1030.6±34.3 °C |
| Exact Mass | 1709.968872 |
| LogP | -4.24 |
| Vapour Pressure | 0.0±0.6 mmHg at 25°C |
| Index of Refraction | 1.579 |
| 21-[(2-Acetamido-2-deoxy-β-D-galactopyranosyl)oxy]-N-[3-({5-[(2-acetamido-2-deoxy-β-D-galactopyranosyl)oxy]pentanoyl}amino)propyl]-6-[(3-{[3-({5-[(2-acetamido-2-deoxy-β-D-galactopyranosyl)oxy ]pentanoyl}amino)propyl]amino}-3-oxopropoxy)methyl]-6-({12-[(2R,4R)-4-hydroxy-2-methyl-1-pyrrolidinyl]-12-oxododecanoyl}amino)-11,17-dioxo-4,8-dioxa-12,16-diazahenicosan-1-amide |
| 1-Pyrrolidinedodecanamide, N-[2-[3-[[3-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]propyl]amino]-3-oxopropoxy]-1,1-bis[[3-[[3-[[5-[[2-(acetylamino)-2-deoxy-β-D-gala ctopyranosyl]oxy]-1-oxopentyl]amino]propyl]amino]-3-oxopropoxy]methyl]ethyl]-4-hydroxy-2-methyl-λ-oxo-, (2R,4R)- |