OD 36 HCl
Modify Date: 2024-01-14 19:45:53
OD 36 HCl structure
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Common Name | OD 36 HCl | ||
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| CAS Number | 1638644-62-8 | Molecular Weight | 367.230 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C16H15ClN4O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of OD 36 HClRIPK2 inhibitor OD36 is a potent, specific, ATP-competitive inhibitor of RIPK2 with IC50 of 5.3 nM, inhibits Tyr and Ser/Thr-directed activities of RIPK2; inhibits both RIPK2 tyrosine autophosphorylation as well as downstream NF-κB and MAPK signaling induced by MDP, downregulates a panel of RIPK2 kinase-dependent genes; reduces cellular infiltration in an in vivo MDP-induced peritonitis model; also shows high affinity for cyclin G-associated kinase (GAK) with Ki of 3.8 nM. |
| Name | 4-Chloro-7,10-dioxa-13,17,18,21-tetraazatetracyclo[12.5.2.12,6.017,20]docosa-1(20),2(22),3,5,14(21),15,18-heptaene hydrochloride (1:1) |
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| Synonym | More Synonyms |
| Description | RIPK2 inhibitor OD36 is a potent, specific, ATP-competitive inhibitor of RIPK2 with IC50 of 5.3 nM, inhibits Tyr and Ser/Thr-directed activities of RIPK2; inhibits both RIPK2 tyrosine autophosphorylation as well as downstream NF-κB and MAPK signaling induced by MDP, downregulates a panel of RIPK2 kinase-dependent genes; reduces cellular infiltration in an in vivo MDP-induced peritonitis model; also shows high affinity for cyclin G-associated kinase (GAK) with Ki of 3.8 nM. |
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| References | References 1. Tigno-Aranjuez JT, et al. J Biol Chem. 2014 Oct 24;289(43):29651-64. 2. Asquith CRM, et al. J Med Chem. 2019 Feb 15. doi: 10.1021/acs.jmedchem.8b01213. View Related Products by Target RIP kinase |
| Molecular Formula | C16H15ClN4O2 |
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| Molecular Weight | 367.230 |
| Exact Mass | 366.065033 |
| 4-Chloro-7,10-dioxa-13,17,18,21-tetraazatetracyclo[12.5.2.12,6.017,20]docosa-1(20),2(22),3,5,14(21),15,18-heptaene hydrochloride (1:1) |
| 1,16-Etheno-8,4-metheno-13H-pyrazolo[3,4-g][1,14,4,6]dioxadiazacyclohexadecine, 6-chloro-10,11,14,15-tetrahydro-, hydrochloride (1:1) |