TH287 hydrochloride
Modify Date: 2024-01-14 10:48:29
TH287 hydrochloride structure
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Common Name | TH287 hydrochloride | ||
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| CAS Number | 1638211-05-8 | Molecular Weight | 305.591 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C11H11Cl3N4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of TH287 hydrochlorideTH287 hydrochloride is a potent inhibitor of MTH1 (NUDT1) with an IC50 value of 0.8 nM, less potent for MTH2, NUDT5, NUDT12, NUDT14, and NUDT16.IC50 value: 0.8 nM [1]Target: MTH1 inhibitorTH287 is considered a new target for cancer therapy. TH287 is highly selective towards MTH1, with no relevant inhibition of other members of the nudix protein family. TH287 has been shown to selectively kill a variety of cancer cell lines, but is rapidly metablized, so not as useful for in vivo studies. |
| Name | TH287 hydrochloride |
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| Synonym | More Synonyms |
| Description | TH287 hydrochloride is a potent inhibitor of MTH1 (NUDT1) with an IC50 value of 0.8 nM, less potent for MTH2, NUDT5, NUDT12, NUDT14, and NUDT16.IC50 value: 0.8 nM [1]Target: MTH1 inhibitorTH287 is considered a new target for cancer therapy. TH287 is highly selective towards MTH1, with no relevant inhibition of other members of the nudix protein family. TH287 has been shown to selectively kill a variety of cancer cell lines, but is rapidly metablized, so not as useful for in vivo studies. |
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| Related Catalog | |
| References |
| Molecular Formula | C11H11Cl3N4 |
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| Molecular Weight | 305.591 |
| Exact Mass | 304.004944 |
| Storage condition | 2-8℃ |
| 2,4-Pyrimidinediamine, 6-(2,3-dichlorophenyl)-N4-methyl-, hydrochloride (1:1) |
| 6-(2,3-Dichlorophenyl)-N4-methyl-2,4-pyrimidinediamine hydrochloride (1:1) |
| TH287 (hydrochloride) |