Kadsulignan N

Modify Date: 2025-08-25 23:45:42

Kadsulignan N Structure
Kadsulignan N structure
 Common Name Kadsulignan N
CAS Number 163564-58-7 Molecular Weight 430.491
Density 1.1±0.1 g/cm3 Boiling Point 545.1±50.0 °C at 760 mmHg
Molecular Formula C24H30O7 Melting Point N/A
MSDS N/A Flash Point 217.0±30.0 °C

 Use of Kadsulignan N


Kadsulignan N, a natural product has anti-HIV activity (EC50: 43.56 μM). Kadsulignan N is also a COX-2 ligand (Ki: 72.24 nM)[1][2].

 Names

Name (1R,14S,15S,16R)-4,5,6,9,10,11-Hexamethoxy-15,16-dimethyl-17-oxatetracyclo[12.2.1.02,7.08,13]heptadeca-2,4,6,8,10,12-hexaene
Synonym More Synonyms

 Kadsulignan N Biological Activity

Description Kadsulignan N, a natural product has anti-HIV activity (EC50: 43.56 μM). Kadsulignan N is also a COX-2 ligand (Ki: 72.24 nM)[1][2].
Related Catalog
Target

COX-2

In Vitro Kadsulignans N 对 COX-2 表现出较弱的抑制活性，IC50值为 600.54 μM[2]。
References

[1]. Gao XM, et al. Lignans from Kadsura angustifolia. J Nat Prod. 2008 Apr;71(4):558-63.  

[2]. Zhang XY, et al. Discovery of cyclooxygenase-2 inhibitors from Kadsura coccinea by affinity ultrafiltration mass spectrometry and the anti-inflammatory activity. Fitoterapia. 2021 Jun;151:104872.  

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 545.1±50.0 °C at 760 mmHg
Molecular Formula C24H30O7
Molecular Weight 430.491
Flash Point 217.0±30.0 °C
Exact Mass 430.199158
PSA 64.61000
LogP 4.24
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.535

 Synonyms

(1R,14S,15S,16R)-4,5,6,9,10,11-Hexamethoxy-15,16-dimethyl-17-oxatetracyclo[12.2.1.0.0]heptadeca-2,4,6,8,10,12-hexaene
5,8-Epoxydibenzo[a,c]cyclooctene, 5,6,7,8-tetrahydro-1,2,3,10,11,12-hexamethoxy-6,7-dimethyl-, (5R,6R,7S,8S)-
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