Kadsulignan N

Names

[ Name ]:
Kadsulignan N

[Synonym ]:
(1R,14S,15S,16R)-4,5,6,9,10,11-Hexamethoxy-15,16-dimethyl-17-oxatetracyclo[12.2.1.0.0]heptadeca-2,4,6,8,10,12-hexaene
5,8-Epoxydibenzo[a,c]cyclooctene, 5,6,7,8-tetrahydro-1,2,3,10,11,12-hexamethoxy-6,7-dimethyl-, (5R,6R,7S,8S)-

Biological Activity

[Description]:

Kadsulignan N, a natural product has anti-HIV activity (EC50: 43.56 μM). Kadsulignan N is also a COX-2 ligand (Ki: 72.24 nM)[1][2].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HIV

Research Areas >> Infection

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Immunology/Inflammation >> COX

[Target]

COX-2

[In Vitro]

Kadsulignans N 对 COX-2 表现出较弱的抑制活性，IC50值为 600.54 μM[2]。

[References]

[1]. Gao XM, et al. Lignans from Kadsura angustifolia. J Nat Prod. 2008 Apr;71(4):558-63.

[2]. Zhang XY, et al. Discovery of cyclooxygenase-2 inhibitors from Kadsura coccinea by affinity ultrafiltration mass spectrometry and the anti-inflammatory activity. Fitoterapia. 2021 Jun;151:104872.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
545.1±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₄H₃₀O₇

[ Molecular Weight ]:
430.491

[ Flash Point ]:
217.0±30.0 °C

[ Exact Mass ]:
430.199158

[ PSA ]:
64.61000

[ LogP ]:
4.24

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.535

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.