Clevudine

Modify Date: 2024-01-03 21:09:33

Clevudine Structure
Clevudine structure
 Common Name Clevudine
CAS Number 163252-36-6 Molecular Weight 260.21900
Density 1.55g/cm3 Boiling Point N/A
Molecular Formula C10H13FN2O5 Melting Point 184-185°
MSDS N/A Flash Point N/A

 Use of Clevudine


Clevudine is an antiviral drug for the treatment of hepatitis B. Target: HBVClevudine is a nucleoside analog with an unnatural beta-L configuration. Clevudine showed potent antiviral activity during therapy and induced a sustained posttreatment antiviral effect for 6 months after a 12-week treatment period, and this was associated with a sustained normalization of ALT levels [1]. Clevudine showed a potent antiviral response, and its effect was higher in HBeAg-negative patients, with rapid viral load reduction after therapy. However, long-term therapy for more than 1 year resulted in the development of considerable resistance and myopathy. Therefore, we should consider alternative antiviral agents if clevudine resistance or clevudine-induced myopathy is developed in patients on clevudine for the treatment of CHB [2].

 Names

Name 1-((2S,3R,4S,5S)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
Synonym More Synonyms

 Clevudine Biological Activity

Description Clevudine is an antiviral drug for the treatment of hepatitis B. Target: HBVClevudine is a nucleoside analog with an unnatural beta-L configuration. Clevudine showed potent antiviral activity during therapy and induced a sustained posttreatment antiviral effect for 6 months after a 12-week treatment period, and this was associated with a sustained normalization of ALT levels [1]. Clevudine showed a potent antiviral response, and its effect was higher in HBeAg-negative patients, with rapid viral load reduction after therapy. However, long-term therapy for more than 1 year resulted in the development of considerable resistance and myopathy. Therefore, we should consider alternative antiviral agents if clevudine resistance or clevudine-induced myopathy is developed in patients on clevudine for the treatment of CHB [2].
Related Catalog
References

[1]. Lee, H.S., et al., A 12-week clevudine therapy showed potent and durable antiviral activity in HBeAg-positive chronic hepatitis B. Hepatology, 2006. 43(5): p. 982-8.

[2]. Jang, J.H., et al., Clevudine for chronic hepatitis B: antiviral response, predictors of response, and development of myopathy. J Viral Hepat, 2011. 18(2): p. 84-90.

 Chemical & Physical Properties

Density 1.55g/cm3
Melting Point 184-185°
Molecular Formula C10H13FN2O5
Molecular Weight 260.21900
Exact Mass 260.08100
PSA 104.55000
Index of Refraction 1.592
Storage condition -20°C

 Safety Information

Hazard Codes Xi
HS Code 2934999090

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

CLEVUDINE
Clevudine
Levovir
L-FMAU
Top Suppliers:I want be here

Get all suppliers and price by the below link:

Clevudine suppliers

Price: ￥577.2/1mg

Reference only. check more Clevudine price

Related Compounds: More...
CLEVUDINE
172494-45-0
Clevudine F-18
1027764-69-7
Chemsrc provides Clevudine(CAS#:163252-36-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Clevudine are included as well.>> amp version: Clevudine

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved