CHDI 00390576
Modify Date: 2024-01-14 13:57:27
CHDI 00390576 structure
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Common Name | CHDI 00390576 | ||
|---|---|---|---|---|
| CAS Number | 1629729-98-1 | Molecular Weight | 391.32 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H13F4N3O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CHDI 00390576CHDI-390576, a potent, cell permeable and CNS penetrant class IIa histonedeacetylase (HDAC) inhibitor with IC50s of 54 nM, 60 nM, 31 nM, 50 nM for class IIa HDAC4, HDAC5, HDAC7, HDAC9, respectively, shows >500-fold selectivity over class I HDACs (1, 2, 3) and ~150-fold selectivity over HDAC8 and the class IIb HDAC6 isoform[1]. |
| Name | CHDI-390576 |
|---|
| Description | CHDI-390576, a potent, cell permeable and CNS penetrant class IIa histonedeacetylase (HDAC) inhibitor with IC50s of 54 nM, 60 nM, 31 nM, 50 nM for class IIa HDAC4, HDAC5, HDAC7, HDAC9, respectively, shows >500-fold selectivity over class I HDACs (1, 2, 3) and ~150-fold selectivity over HDAC8 and the class IIb HDAC6 isoform[1]. |
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| Related Catalog | |
| Target |
HDAC4:54 nM (IC50) HDAC5:60 nM (IC50) HDAC7:31 nM (IC50) hHDAC9:50 nM (IC50) HDAC1:39.7 μM (IC50) HDAC3:25.8 μM (IC50) HDAC8:9.1 μM (IC50) hHDAC6:6.2 μM (IC50) |
| In Vitro | The affinity (Kd) of CHDI-390576 to the catalytic domain of immobilized HDAC4 is 80 nM[1]. CHDI-390576 inhibits class I HDACs (1, 3, 8) and class IIb HDAC6 isoforms with IC50s of 39.7μM, 25.8 μM, 9.1 μM, 6.2 μM, respectively[1]. |
| References |
| Molecular Formula | C19H13F4N3O2 |
|---|---|
| Molecular Weight | 391.32 |