Abrocitinib
Modify Date: 2025-08-21 20:04:43
Abrocitinib structure
|
Common Name | Abrocitinib | ||
|---|---|---|---|---|
| CAS Number | 1622902-68-4 | Molecular Weight | 323.415 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C14H21N5O2S | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of AbrocitinibAbrocitinib (PF-04965842) is a potent, oral active and selective JAK1 inhibitor, with IC50s of 29 and 803 nM for JAK1 and JAK2, respectively. Abrocitinib (PF-04965842) exhibits less active effect on TYK2 (IC50, 1.253 μM), and inhibits phosphorylation of STAT1,STAT3 and STAT5 after stimulation. Effective in autoimmune disease[1]. |
| Name | PF-04965842 |
|---|---|
| Synonym | More Synonyms |
| Description | Abrocitinib (PF-04965842) is a potent, oral active and selective JAK1 inhibitor, with IC50s of 29 and 803 nM for JAK1 and JAK2, respectively. Abrocitinib (PF-04965842) exhibits less active effect on TYK2 (IC50, 1.253 μM), and inhibits phosphorylation of STAT1,STAT3 and STAT5 after stimulation. Effective in autoimmune disease[1]. |
|---|---|
| Related Catalog | |
| Target |
JAK1:29 nM (IC50) JAK2:803 nM (IC50) Tyk2:1253 nM (IC50) |
| In Vitro | Abrocitinib (Compound 25) inhibits IFNα-stimulated phosphorylation of STAT3, IFN-stimulated phosphorylation of STAT1 in human whole blood (HWB), as well as pSTAT5 in CD34+ spiked into HWB (JAK2), with IC50s of 189, 163 nM, 7.178 μM, respectively[1]. |
| References |
| Molecular Formula | C14H21N5O2S |
|---|---|
| Molecular Weight | 323.415 |
| Storage condition | 2-8℃ |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Precautionary Statements | P301 + P312 + P330 |
| RIDADR | NONH for all modes of transport |
| Abrocitinib |