ONO-7579
Modify Date: 2025-08-30 13:15:19
ONO-7579 structure
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Common Name | ONO-7579 | ||
|---|---|---|---|---|
| CAS Number | 1622212-25-2 | Molecular Weight | 578.951 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C24H18ClF3N6O4S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ONO-7579ONO-7579 (ONO7579) is a novel potent, selective, orally available pan-TRK inhibitor.BDNF significantly increased TRKB phosphorylation in GBC cells and the effects were abrogated by ONO-7579, suppress proliferation in a dose-dependent manner in TYGBK-1 cells.ONO-7579 inhibited BDNF/TRKB-induced migration and invasiveness, particularly in GBC cells harboring wild-type KRAS.ONO-7579 reduced invasiveness of gallbladder cancer (GBC) cells through inhibiting epithelial–mesenchymal transition (EMT) via the extracellular signal-regulated kinase (ERK) or protein kinase B (AKT) pathway. |
| Name | ONO-7579 |
|---|
| Description | ONO-7579 (ONO7579) is a novel potent, selective, orally available pan-TRK inhibitor.BDNF significantly increased TRKB phosphorylation in GBC cells and the effects were abrogated by ONO-7579, suppress proliferation in a dose-dependent manner in TYGBK-1 cells.ONO-7579 inhibited BDNF/TRKB-induced migration and invasiveness, particularly in GBC cells harboring wild-type KRAS.ONO-7579 reduced invasiveness of gallbladder cancer (GBC) cells through inhibiting epithelial–mesenchymal transition (EMT) via the extracellular signal-regulated kinase (ERK) or protein kinase B (AKT) pathway. |
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| References | 1. Kawamoto M, et al. Anticancer Res. 2018 Apr;38(4):1979-1986. 2. Iida H, et al. J Pharmacol Exp Ther. 2020 Jun;373(3):361-369. |
| Molecular Formula | C24H18ClF3N6O4S |
|---|---|
| Molecular Weight | 578.951 |
| InChIKey | GYPOVJZOMXEUDO-UHFFFAOYSA-N |
| SMILES | CS(=O)(=O)c1ccc(C(F)(F)F)cc1NC(=O)Nc1cnc(Oc2ccc(-c3cc(Cl)cnc3N)cc2)nc1 |